The solution stability of this product has not been determined. However, historical data suggest that solutions in methanol are stable for several weeks when stored refrigerated and protect from light. Manufacturers of aqueous solutions in sodium chloride for therapeutic use indicate a shelf life of 6 months when stored refrigerated and protect from light.
V4629
(±)-Verapamil hydrochloride
≥99% (titration), powder, α1-adrenoceptor antagonist
Sinónimos:
5-[N-(3,4-Dimethoxyphenylethyl)methylamino]-2-(3,4-dimethoxyphenyl)-2-isopropylvaleronitrile hydrochloride
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| Talla/SKU | Disponibilidad | Precio |
|---|---|---|
1 g | Póngase en contacto con nuestro Servicio de Atención al Cliente para disponibilidad | 112,00 € |
5 g | Póngase en contacto con nuestro Servicio de Atención al Cliente para disponibilidad | 410,00 € |
10 g | Póngase en contacto con nuestro Servicio de Atención al Cliente para disponibilidad | 810,00 € 688,50 € |
Acerca de este artículo
Fórmula lineal:
(CH3O)2C6H3CH2CH2N(CH3)(CH2)3C[C6H3(OCH3)2][CH(CH3)2]CN · HCl
Número CAS:
Peso molecular:
491.06
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352200
EC Number:
205-800-5
MDL number:
Beilstein/REAXYS Number:
3647093
Assay:
≥99% (titration)
Form:
powder
112,00 €
Póngase en contacto con nuestro Servicio de Atención al Cliente para disponibilidad
Servicio técnico
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Permítanos ayudarleNombre del producto
(±)-Verapamil hydrochloride, ≥99% (titration), powder
Quality Segment
assay
≥99% (titration)
form
powder
color
white
mp
142 °C (dec.) (lit.)
solubility
methanol: 50 mg/mL, ethanol: soluble
SMILES string
Cl.COc1ccc(CCN(C)CCCC(C#N)(C(C)C)c2ccc(OC)c(OC)c2)cc1OC
InChI
1S/C27H38N2O4.ClH/c1-20(2)27(19-28,22-10-12-24(31-5)26(18-22)33-7)14-8-15-29(3)16-13-21-9-11-23(30-4)25(17-21)32-6;/h9-12,17-18,20H,8,13-16H2,1-7H3;1H
InChI key
DOQPXTMNIUCOSY-UHFFFAOYSA-N
Gene Information
human ... ADRA1A(148), ADRA1B(147), ADRA1D(146), CACNA1C(775), CACNA1D(776), CACNA1F(778), CACNA1S(779)
Application
Biochem/physiol Actions
α1-adrenoceptor antagonist; L-type calcium channel blocker.
α1-adrenoceptor antagonist; L-type calcium channel blocker. Blocks L-type Ca2+ channels in smooth and cardiac muscle, induces apoptosis of human primary and metastatic colon adenocarcinoma cells in vitro. Drug resistance reversal agent acting on Pgp, e.g. decrease renal tubule elimination of digoxin. Increases basal ATPase activity of Pgp. Substrate of Cyp3A4 and CYP2C6.
Features and Benefits
This compound is a featured product for ADME Tox research. Click here to discover more featured ADME Tox products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.
This compound is featured on the Calcium Channels page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
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Este artículo | |||
|---|---|---|---|
| description ≥99% (titration), powder | description A papaverine derivative that blocks Ca2+ channels (principally the L-type) in smooth and cardiac muscle cells. | description European Pharmacopoeia (EP) Reference Standard | description British Pharmacopoeia (BP) Reference Standard |
| assay ≥99% (titration) | assay ≥99% (perchloric acid titration) | assay - | assay - |
| form powder | form solid | form - | form solid |
| Quality Level 100 | Quality Level 100 | Quality Level - | Quality Level - |
| solubility methanol: 50 mg/mL, ethanol: soluble | solubility water: 70 mg/mL, methanol: 50 mg/mL, ethanol: soluble | solubility - | solubility - |
| Gene Information human ... ADRA1A(148), ADRA1B(147), ADRA1D(146), CACNA1C(775), CACNA1D(776), CACNA1F(778), CACNA1S(779) | Gene Information - | Gene Information human ... CACNA1C(775), CACNA1D(776), CACNA1F(778), CACNA1S(779) | Gene Information human ... CACNA1C(775), CACNA1D(776), CACNA1F(778), CACNA1S(779) |
| mp 142 °C (dec.) (lit.) | mp - | mp 142 °C (dec.) (lit.) | mp 142 °C (dec.) (lit.) |
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Danger
Códigos de peligro
Indicaciones de precaución
Hazard Classifications
Acute Tox. 3 Oral - Aquatic Chronic 2
Clase de almacenamiento
6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
¿Qué está pasando?
WGK 3
Punto de inflamación (°F)
Not applicable
Punto de inflamación (°C)
Not applicable
EPI (equipos de protección individual)
Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges
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