M2525

Mianserin hydrochloride

• Sinónimos: 1,2,3,4,10,14b-Hexahydro-2-methyl-dibenzo[c,f]pyrazino[1,2-a]azepine hydrochloride
• Fórmula empírica (notación de Hill): C₁₈H₂₀N₂ · HCl
• Número de CAS: 21535-47-7
• Peso molecular: 300.83
• Número CE: 244-426-7
• Número MDL: MFCD00055072
• Código UNSPSC: 12352200
• ID de la sustancia en PubChem: 24278125
• NACRES: NA.77

Propiedades

• Nivel de calidad: 200
• solubilidad: H₂O: 3.4 mg/mL; ethanol: 5.6 mg/mL
• emisor: Organon
• temp. de almacenamiento: 2-8°C
• cadena SMILES: Cl.CN1CCN2C(C1)c3ccccc3Cc4ccccc24
• InChI: 1S/C18H20N2.ClH/c1-19-10-11-20-17-9-5-3-7-15(17)12-14-6-2-4-8-16(14)18(20)13-19;/h2-9,18H,10-13H2,1H3;1H
• Clave InChI: YNPFMWCWRVTGKJ-UHFFFAOYSA-N
• Información sobre el gen: human ... ADRA2A(150) , ADRA2B(151) , ADRA2C(152) , HRH1(3269) , HTR2A(3356) , HTR2B(3357) , HTR2C(3358)

Descripción

Aplicación

Mianserin hydrochloride has been used:

• as a reversible antagonist for serotonergic -protein coupled receptor (GPCR) - G-protein protein-coupled receptor (S7.1R)[1]
• as an antidepressant in hippocampal astrocytes to test its effect on brain-derived neurotrophic factor (BDNF) mRNA expression[2]
• as a 5-hydroxytryptamine (5-HT) receptor antagonist to study its effect on serotonin modulation[3]

Acciones bioquímicas o fisiológicas

Antidepressant; antagonist/inverse agonist at 5-HT₂ serotonin receptors; also blocks the H₁ histamine receptor and the α₂ adrenoceptor.

Mianserin is a tetracyclic compound with sedative property.[4] It lacks anticholinergic activity and is not effective on serotoninergic mechanisms.[4] Mianserin is eliminated post biotransformation as hydroxylation, N-oxidation and N-demethylation products.[4]

Características y beneficios

This compound was developed by Organon. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Nota de preparación

Solutions may be stored for several days at 4°C.

Información de seguridad

• Pictogramas: GHS07
• Palabra de señalización: Warning
• Frases de peligro: H302
• Clasificaciones de peligro: Acute Tox. 4 Oral
• Código de clase de almacenamiento: 11 - Combustible Solids
• Clase de riesgo para el agua (WGK): WGK 3
• Punto de inflamabilidad (°F): Not applicable
• Punto de inflamabilidad (°C): Not applicable
• Equipo de protección personal: dust mask type N95 (US), Eyeshields, Gloves