L1381
L-α-Lysophosphatidylcholine from bovine brain
≥99%, Type V
Sinónimos:
1-Acyl-sn-glycero-3-phosphocholine, L-α-Lysolecithin
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About This Item
Productos recomendados
descripción
zwitterionic
tpo
Type V
Ensayo
≥99%
tipo de lípido
phospholipids
temp. de almacenamiento
−20°C
Descripción general
Aplicación
L-α-Lysophosphatidylcholine from bovine brain has been used:
- to determine the dose-dependent high-mobility group box 1 (HMGB1) release in macrophage and monocyte cultures by production of lysophosphatidylcholine (LPC)[3]
- for lysolecithin demyelination of mice brain tissue[4]
- for demyelination of axons[5]
Acciones bioquímicas o fisiológicas
L-α-Lysophosphatidylcholine possess cytotoxic effects and is present at high level in ischemia and atherosclerotic aortas.[2]
Lysophosphatidylcholine is a major component of oxidized low density lipoproteins, and has been implicated in various inflammatory reactions, including atherosclerosis.
Lysophosphatidylcholine is a major component of oxidized low density lipoproteins, and has been implicated in various inflammatory reactions, including atherosclerosis. It is a degradation product of phosphatidylcholine by phospholipase A and has cytolytic properties. The product is used to demyelinate spinal neurons and study the processes underlying remyelination. It activates protein kinase C, p38 MAP kinase, p42 MAP Kinase, and the jun kinase (JNK) pathway, and stimulates transcription of c-jun. Lysophosphatidylcholine accumulates during cardiac ischemia and may induce arrhythmias by uncoupling gap junction communication, and increase ischemic damage by enhancing Na+ loading in cardiac myocytes. It also activates TREK1, TREK2 and TRAAK K+ channels.
Características y beneficios
This compound is featured on the Phospholipase D page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
Otras notas
Contains primarily palmitic, stearic and oleic acids.
Código de clase de almacenamiento
11 - Combustible Solids
Clase de riesgo para el agua (WGK)
WGK 3
Punto de inflamabilidad (°F)
Not applicable
Punto de inflamabilidad (°C)
Not applicable
Equipo de protección personal
Eyeshields, Gloves, type N95 (US)
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Myelin regulatory factor drives remyelination in multiple sclerosis
Duncan GJ, et al.
Acta neuropathologica, 134(3), 403-422 (2017)
Characterization of plasma unsaturated lysophosphatidylcholines in human and rat
CROSET M, et al.
The Biochemical Journal, 345(1), 61-67 (2000)
Suppression of HMGB1 release by stearoyl lysophosphatidylcholine:an additional mechanism for its therapeutic effects in experimental sepsis
Chen G, et al.
Journal of Lipid Research, 46(4), 623-627 (2005)
Bilal El Waly et al.
Frontiers in cellular neuroscience, 14, 165-165 (2020-07-14)
Demyelination and axon degeneration are major events in all neurodegenerative diseases, including multiple sclerosis. Intoxication of oligodendrocytes with lysophosphatidylcholine (LPC) is often used as a selective model of focal and reversible demyelination thought to have no incidence for neurons. To
Metabolism and atherogenic disease association of lysophosphatidylcholine
Schmitz G and Ruebsaamen K
Atherosclerosis, 208(1), 10-18 (2010)
Filtros activos
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