F7930
FGFR3 (397-end), active, GST tagged human
PRECISIO® Kinase, recombinant, expressed in baculovirus infected Sf9 cells, ≥70% (SDS-PAGE), buffered aqueous glycerol solution
Sinónimos:
Eph receptor tyrosine kinase, growth hormone receptor, ACH, CD333, CEK2, HSFGFR3EX, JTK4
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10 μG
533,00 €
533,00 €
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10 μG
533,00 €
About This Item
Código UNSPSC:
51111800
NACRES:
NA.32
533,00 €
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origen biológico
human
Nivel de calidad
recombinante
expressed in baculovirus infected Sf9 cells
Línea del producto
PRECISIO® Kinase
Ensayo
≥70% (SDS-PAGE)
Formulario
buffered aqueous glycerol solution
actividad específica
95-129 nmol/min·mg
mol peso
~73 kDa
envase
pkg of 10 μg
técnicas
cell based assay: suitable
solubilidad
water: soluble
Nº de acceso Protein ID
Nº de acceso UniProt
Condiciones de envío
dry ice
temp. de almacenamiento
−70°C
Información sobre el gen
human ... FGFR3(2261)
Descripción general
Research area: Cancer
FGFR3 (fibroblast growth factor receptor 3) is a receptor tyrosine kinase (RTK) and belongs to the FGFR subfamily. This subfamily includes four members namely, FGFR1, FGFR2, FGFR3, and FGFR4. It contains a ligand-binding region in its exoplasmic domain, a single transmembrane region, and a tyrosine kinase domain in its intracellular domain.[1]FGFR3 has a strong affinity for canonical FGF ligands.[2]
FGFR3 (fibroblast growth factor receptor 3) is a receptor tyrosine kinase (RTK) and belongs to the FGFR subfamily. This subfamily includes four members namely, FGFR1, FGFR2, FGFR3, and FGFR4. It contains a ligand-binding region in its exoplasmic domain, a single transmembrane region, and a tyrosine kinase domain in its intracellular domain.[1]FGFR3 has a strong affinity for canonical FGF ligands.[2]
Acciones bioquímicas o fisiológicas
FGFR3 (fibroblast growth factor receptor 3) plays an essential role in the signaling pathways during embryogenesis and angiogenesis. [3] This gene is either mutated or up-regulated in multiple myeloma, cervical carcinoma [3] and nonmuscle-invasive urothelial carcinoma (UC) of the bladder.[4]Apart from this, certain mutations in FGFR3 are also known to be linked with skeletal disorders such as various forms of dwarfism. [3] FGFR3 also plays hepatoprotective function during liver damage. [5]
Forma física
Supplied in 50 mM Tris-HCl, pH 7.5, with 150 mM NaCl, 0.2 5mM DTT, 0.1 mM EGTA, 0.1 mM EDTA, 0.1 mM PMSF, and 25% glycerol.
Información legal
PRECISIO is a registered trademark of Merck KGaA, Darmstadt, Germany
Código de clase de almacenamiento
10 - Combustible liquids
Clase de riesgo para el agua (WGK)
WGK 1
Punto de inflamabilidad (°F)
Not applicable
Punto de inflamabilidad (°C)
Not applicable
Equipo de protección personal
Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)
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Corine G M L'Hôte et al.
Experimental cell research, 304(2), 417-431 (2005-03-08)
FGFR3 is a receptor tyrosine kinase (RTK) of the FGF receptor family, known to have a negative regulatory effect on long bone growth. Fgfr3 knockout mice display longer bones and, accordingly, most germline-activating mutations in man are associated with dwarfism.
Lin Chen et al.
Frontiers in bioscience : a journal and virtual library, 10, 1961-1976 (2005-03-17)
Fibroblast growth factor receptors (FGFRs) exist as a gene family of 4 membrane bound receptor tyrosine kinases (FGFR1-4) that mediate signals of at least 22 fibroblast growth factors (FGF1-22). FGFs/FGFRs play important roles in multiple biological processes, including mesoderm induction
Elizabeth A Guancial et al.
Cancer medicine, 3(4), 835-844 (2014-05-23)
While fibroblast growth factor receptor 3 (FGFR3) is frequently mutated or overexpressed in nonmuscle-invasive urothelial carcinoma (UC), the prevalence of FGFR3 protein expression and mutation remains unknown in muscle-invasive disease. FGFR3 protein and mRNA expression, mutational status, and copy number
Hiroko Tamagaki et al.
Biochemistry, 53(30), 5000-5007 (2014-07-11)
Activation of the protein tyrosine kinase receptors requires the coupling of ligand binding to a change in both the proximity and orientation of the single transmembrane (TM) helices of receptor monomers to allow transphosphorylation of the receptor kinase domain. We
FGFR3 biology and skeletal disease
Jyoti Narayana and William A Horton
Connective tissue research, 56(6), 427-433 (2015)
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