M1891
Myelin Basic Protein bovine
≥90% (SDS-PAGE), lyophilized powder, suitable for activity assay
Sinónimos:
MBP
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About This Item
Productos recomendados
origen biológico
bovine
Análisis
≥90% (SDS-PAGE)
formulario
lyophilized powder
mol peso
18.4 kDa
condiciones de almacenamiento
(Keep container tightly closed in a dry and well-ventilated place)
técnicas
activity assay: suitable
solubilidad
water: 1 mg/mL, clear, colorless to faintly yellow
Nº de acceso UniProt
temp. de almacenamiento
−20°C
Información sobre el gen
cow ... MBP(618684)
Descripción general
Research Area: Cell Signaling
Myelin basic protein (MBP), a single-chain polypeptide consisting of 170 amino acids with a methyl-arginine, is a peripheral membrane protein. This crucial structural component of the myelin sheath is the second-most abundant protein in myelin representing about 30% of the total myelin protein.
Myelin basic protein (MBP), a single-chain polypeptide consisting of 170 amino acids with a methyl-arginine, is a peripheral membrane protein. This crucial structural component of the myelin sheath is the second-most abundant protein in myelin representing about 30% of the total myelin protein.
Aplicación
Myelin Basic Protein (MBP) bovine has been used:
- in in vitro methylation reaction
- as a substrate in in vitro immunoprecipitation-kinase assay to measure Cds1 (the S-phase-specific checkpoint effector kinase) activity
- to prepare phosphorylated MBP, which is used as a substrate in phosphatase assays
Used as a kinase substrate.
Acciones bioquímicas o fisiológicas
Mutation of the myelin basic protein gene induces dysmyelination. It is used to induce experimental allergic encephalomyelitis.
Myelin basic protein (MBP) plays a vital role in the formation of the myelin sheath and is associated with various neurological disorders. MBP functions as an antigenic target in the autoimmune disease experimental allergic encephalomyelitis (EAE). MBP plays an essential role in cytoskeletal turnover and membrane extension. Additionally, it is also involved in Fyn-mediated signaling pathways, sequestration of phosphoinositide, and regulation of calcium homoeostasis. MBP functions as an in vitro substrate for mitogen-activated protein kinase (MAP) kinase and aids in the purification and functional studies of enzymes.MBP serves as a potential neuroreceptor. It can stimulate the proliferation of lymphocytes in vitro. MBP plays a key role as a substrate in the mitogen-activated protein (MAP) kinase activation pathway. Based on lymphocyte stimulation, MBP can be used to detect cancer. It is used in several immunological studies. MBP also contributes to the preservation of the lipid: protein organization within myelin.
Calidad
May contain traces of urea-glycine buffer salts.
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Código de clase de almacenamiento
11 - Combustible Solids
Clase de riesgo para el agua (WGK)
WGK 3
Punto de inflamabilidad (°F)
Not applicable
Punto de inflamabilidad (°C)
Not applicable
Equipo de protección personal
Eyeshields, Gloves, type N95 (US)
Certificados de análisis (COA)
Busque Certificados de análisis (COA) introduciendo el número de lote del producto. Los números de lote se encuentran en la etiqueta del producto después de las palabras «Lot» o «Batch»
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