D6821

Donepezil hydrochloride

≥98% (HPLC), powder, acetylcholinesterase inhibitor

• Sinónimos: 1H-Inden-1-one, 2,3-dihydro-5,6-dimethoxy-2-[[1-(phenylmethyl)-4-piperidinyl]methyl]-, hydrochloride, E2020
• Fórmula empírica (notación de Hill): C₂₄H₂₉NO₃ · HCl
• Número de CAS: 120011-70-3
• Peso molecular: 415.95
• Número MDL: MFCD00881312
• Código UNSPSC: 12352200
• ID de la sustancia en PubChem: 329798838
• NACRES: NA.77

Propiedades

• Nombre del producto: Donepezil hydrochloride, ≥98% (HPLC)
• Nivel de calidad: 100
• Ensayo: ≥98% (HPLC)
• Formulario: powder
• condiciones de almacenamiento: desiccated
• color: white to off-white
• solubilidad: DMSO: ≥20 mg/mL; H₂O: ≥20 mg/mL
• temp. de almacenamiento: room temp
• cadena SMILES: O=C1C(CC2CCN(CC3=CC=CC=C3)CC2)CC4=CC(OC)=C(OC)C=C41.[H]Cl
• InChI: 1S/C24H29NO3.ClH.H2O/c1-27-22-14-19-13-20(24(26)21(19)15-23(22)28-2)12-17-8-10-25(11-9-17)16-18-6-4-3-5-7-18;;/h3-7,14-15,17,20H,8-13,16H2,1-2H3;1H;1H2
• Clave InChI: HLJIZAKUNCTCQX-UHFFFAOYSA-N
• Información sobre el gen: human ... ACHE(43)

Descripción

Aplicación

Donepezil hydrochloride has been used in dose-response experiment to study its efficacy in ameliorating nicotine withdrawal-induced deficits in contextual conditioning in mice.[1] It has also been intraperitoneally injected into rats to study its ability to improve social behavioral deficits, repetitive behavior and hyperactivity.[2]

Acciones bioquímicas o fisiológicas

Donepezil hydrochloride is a piperidine containing an organic compound and a non-competitive inhibitor.[3] It is useful in treating Alzheimer′s disease, in which dementia is a prominent symptom.[4] Donepezil is shown to induce cognitive ability and overall body function. It has a half-life of 70 hours.[5]

Donepezil monohydrochloride monohydrate is a centrally acting reversible acetylcholinesterase inhibitor.

Características y beneficios

This compound is featured on the Acetylcholine Synthesis and Metabolism page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Información de seguridad

• Pictogramas: GHS06
• Palabra de señalización: Danger
• Frases de peligro: H300,H319
• Consejos de prudencia: P264 - P270 - P280 - P301 + P310 - P305 + P351 + P338 - P337 + P313
• Clasificaciones de peligro: Acute Tox. 2 Oral - Eye Irrit. 2
• Código de clase de almacenamiento: 6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials
• Clase de riesgo para el agua (WGK): WGK 3
• Punto de inflamabilidad (°F): Not applicable
• Punto de inflamabilidad (°C): Not applicable