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C5749
CGP 52608
≥98%, RORA activator, solid
Sinónimos:
1-[3-Allyl-4-oxo-thiazolidine-2-ylidene]-4-methyl-thiosemicarbazone, N-Methyl-2-[4-oxo-3-(2-propen-1-yl)-2-thiazolidinylidene]-hydrazinecarbothioamide
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| Tamaño de envase | SKU | Disponibilidad | Precio |
|---|---|---|---|
| 5 mg | Póngase en contacto con nuestro Servicio de Atención al Cliente para disponibilidad | 149,00 € 126,65 € | |
| 25 mg | Póngase en contacto con nuestro Servicio de Atención al Cliente para disponibilidad | 585,00 € |
Acerca de este artículo
Fórmula empírica (notación de Hill):
C8H12N4OS2
Número CAS:
Peso molecular:
244.34
UNSPSC Code:
12352200
PubChem Substance ID:
NACRES:
NA.77
MDL number:
126,65 €
Precio de catálogo149,00 €Ahorre 15 %Promoción solo por Internet
Póngase en contacto con nuestro Servicio de Atención al Cliente para disponibilidad
Servicio técnico
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Permítanos ayudarleNombre del producto
CGP 52608, ≥98%, solid
Quality Level
assay
≥98%
form
solid
solubility
DMSO: >30 mg/mL, H2O: insoluble
storage temp.
−20°C
SMILES string
CNC(=S)N\N=C1/SCC(=O)N1CC=C
InChI
1S/C8H12N4OS2/c1-3-4-12-6(13)5-15-8(12)11-10-7(14)9-2/h3H,1,4-5H2,2H3,(H2,9,10,14)/b11-8-
InChI key
DDYJDIHOSRTMSE-FLIBITNWSA-N
Application
Biochem/physiol Actions
CGP 52608 is a specific activator of retinoic acid receptor-related orphan receptor α (RORA).
CGP 52608 is a thiazolidine derivative[4] and an antiarthritic compound.[5] It possesses immunostimulatory functionality[4] and elicits antiproliferative effect in colon tumors.[6] It is cytotoxic towards neural cell lines.[5] CGP 52608 induces apoptosis in tumor[6] and also favors G0-G1 cell cycle phase accumulation in neural cell lines.[5]
Features and Benefits
This compound is featured on the Nuclear Receptors (Non-Steroids) page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
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Este artículo | |||
|---|---|---|---|
| assay ≥98% | assay ≥98% (HPLC) | assay ≥98% (HPLC) | assay ≥98% (HPLC) |
| form solid | form powder | form powder | form powder |
| Quality Level 100 | Quality Level 100 | Quality Level 100 | Quality Level 100 |
| storage temp. −20°C | storage temp. 2-8°C | storage temp. −20°C | storage temp. 2-8°C |
| solubility DMSO: >30 mg/mL, H2O: insoluble | solubility DMSO: 15 mg/mL, clear | solubility DMSO: 20 mg/mL, clear | solubility H2O: 10 mg/mL, clear |
Clase de almacenamiento
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
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Artículos
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K Winczyk et al.
Journal of pineal research, 31(2), 179-182 (2001-09-14)
The effects of melatonin and the thiazolinidinedione derivative CGP 52608 on apoptosis of Colon 38 cancer cells were investigated. Male mice were implanted subcutaneously with a suspension of Colon 38 cells. Ten days after induction of tumors, the animals were
M Karasek et al.
Biological signals and receptors, 8(1-2), 75-78 (1999-03-23)
The antiproliferative effects of melatonin and CGP 52608, an exogenous ligand for RZR/ROR receptors, are compared in the present paper. Both compounds exerted similar inhibitory effects on the proliferation of neoplastic cells in mouse colonic adenocarcinoma, DU 145 human prostate
Michal Karasek et al.
Journal of pineal research, 34(4), 294-296 (2003-03-29)
Melatonin exerts a marked antiproliferative action in numerous experimentally-induced tumors in vivo as well as in both animal and human cell lines in vitro. However, the mechanisms of oncostatic action of melatonin is not clear, and the involvement of both
Número de artículo de comercio global
| SKU | GTIN |
|---|---|
| C5749-5MG | 04061832954172 |
| C5749-25MG | 04061832954165 |
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Hi, I wonder how long time I can use it the CGP52608 (C5749) after delivery since there is no expiry date on the CoA ?
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