212385-M

Carbachol

An unsubstituted carbamoyl ester that acts as an agonist for nicotinic and muscarinic acetylcholine receptors.

• Sinónimos: Carbachol, Carbamoylcholine Chloride
• Fórmula empírica (notación de Hill): C₆H₁₅ClN₂O₂
• Número de CAS: 51-83-2
• Peso molecular: 182.65
• Número MDL: MFCD00012011
• Código UNSPSC: 12352200
• NACRES: NA.77

Propiedades

• Nivel de calidad: 100
• Ensayo: ≥98% (titration)
• Formulario: solid (fine crystalline)
• fabricante / nombre comercial: Calbiochem^®
• condiciones de almacenamiento: OK to freeze; desiccated (hygroscopic)
• color: white
• solubilidad: methanol: 100 mg/mL; water: 100 mg/mL; ethanol: 20 mg/mL
• temp. de almacenamiento: 10-30°C
• cadena SMILES: Cl.[N+](CCO\C(=N\[H])\[O-])(C)(C)C
• InChI: 1S/C6H14N2O2.ClH/c1-8(2,3)4-5-10-6(7)9;/h4-5H2,1-3H3,(H-,7,9);1H
• Clave InChI: AIXAANGOTKPUOY-UHFFFAOYSA-N

Descripción

Descripción general

An unsubstituted carbamoyl ester that acts as an agonist for nicotinic and muscarinic acetylcholine receptors. Carbachol is totally resistant to the action of acetylcholine esterase (AChE) and non-specific cholinesterases. Inhibits apoptotic death of cultured granule neurons.

An unsubstituted carbamoyl ester that acts as an agonist for nicotinic and muscarinic acetylcholine receptors. Known to increase cytosolic Ca²⁺ and InsP₃ and decrease cAMP levels. Resistant to the action of acetylcholine esterase (AChE) and non-specific cholinesterases. Inhibits apoptotic death of cultured granule neurons.

Acciones bioquímicas o fisiológicas

Primary Target
Agonist for nicotinic and muscarinic acetylcholine receptors

Advertencia

Toxicity: Highly Toxic (H)

Reconstitución

Following reconstitution, store in the refrigerator (4°C). Stock solutions are stable for up to 6 months at 4°C.

Otras notas

Jence, M., et al. 1995. J. Neurochem. 64, 1605.
Yan, G.M., et al. 1995. Mol. Pharmacol. 47, 248.
Mangels, L.A., and Gnegy, M.E. 1992. J. Biol. Chem.267, 5847.
Watanabe, A.M., et al. 1992. In Basic and Clinical Pharmacology, Fifth Edition Katzung, B.G. ed.) Appleton and Lange, Norwalk, CT, p. 82.
Howe, P.H., et al. 1986. J. Pharmacol. Exp. Ther.239, 574.

Información legal

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Información de seguridad

• Pictogramas: GHS06
• Palabra de señalización: Danger
• Frases de peligro: H300
• Consejos de prudencia: P264 - P270 - P301 + P310 - P405 - P501
• Clasificaciones de peligro: Acute Tox. 2 Oral
• Código de clase de almacenamiento: 6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials
• Clase de riesgo para el agua (WGK): WGK 3
• Punto de inflamabilidad (°F): Not applicable
• Punto de inflamabilidad (°C): Not applicable