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Merck

A1862

Sigma-Aldrich

Alpidem

≥98% (HPLC), powder

Sinónimos:

6-Chloro-2-(4-chlorophenyl)-N,N-dipropyl-imidazo[1,2-a]pyridine-3-acetamide, 6-Chloro-2-(p-chlorophenyl)-N,N-dipropylimidazo(1,2-a)pyridine-3-acetamide, Ananxyl, SL 80.0342-00

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About This Item

Fórmula empírica (notación de Hill):
C21H23Cl2N3O
Número de CAS:
Peso molecular:
404.33
Número MDL:
Código UNSPSC:
12352200
ID de la sustancia en PubChem:

Ensayo

≥98% (HPLC)

Formulario

powder

color

white to tan

solubilidad

DMSO: ≥10 mg/mL

emisor

Sanofi Aventis

temp. de almacenamiento

2-8°C

cadena SMILES

CCCN(CCC)C(=O)Cc1c(nc2ccc(Cl)cn12)-c3ccc(Cl)cc3

InChI

1S/C21H23Cl2N3O/c1-3-11-25(12-4-2)20(27)13-18-21(15-5-7-16(22)8-6-15)24-19-10-9-17(23)14-26(18)19/h5-10,14H,3-4,11-13H2,1-2H3

Clave InChI

JRTIDHTUMYMPRU-UHFFFAOYSA-N

Información sobre el gen

human ... TSPO(706)

Acciones bioquímicas o fisiológicas

Alpidem is a potent antagonist of peripheral benzodiazepine receptor (PBR) that is located on the outer mitochondrial membrane and interacts with the mitochondrial permeability transition (MPT) pore. Alpidem is an anxiolytic drug from the imidazopyridine family. Alpidem acts selectively on the α3 receptor subtype and to a lesser extent at the α1 subtype (Kd of 0.33nM and 1.67nM respectively), of the benzodiazepine receptor.
Alpidem is a potent peripheral benzodiazepine receptor (PBR) antagonist.

Características y beneficios

This compound is a featured product for Neuroscience research. Click here to discover more featured Neuroscience products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.
This compound is featured on the GABAA Receptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
This compound was developed by Sanofi Aventis. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Pictogramas

Exclamation mark

Palabra de señalización

Warning

Frases de peligro

Clasificaciones de peligro

Acute Tox. 4 Oral

Código de clase de almacenamiento

11 - Combustible Solids

Punto de inflamabilidad (°F)

Not applicable

Punto de inflamabilidad (°C)

Not applicable


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The stock market is a source of information on the efficacy and side effects of drugs.
J M Sénard
Methods and findings in experimental and clinical pharmacology, 18 Suppl B, 59-60 (1996-01-01)
P A Maguire et al.
The Journal of pharmacology and experimental therapeutics, 273(2), 842-849 (1995-05-01)
In the present study, we combined a powerful and novel receptor binding data analysis technique. Fourier-derived affinity spectrum analysis (FASA), with the nonlinear regression analysis program LIGAND to resolve benzodiazepine receptor heterogeneity in rat spinal cord. With FASA, we identified
T Bottaï et al.
Clinical neuropharmacology, 18(1), 79-82 (1995-02-01)
We have recently shown that compounds with high affinity for peripheral-type benzodiazepine receptors inhibited glucose-induced insulin secretion in vitro. We therefore performed an oral glucose tolerance test in anxious inpatients treated with the imidazopyridine derivative alpidem, which has been shown
L Flaminio et al.
Journal of chromatography. A, 668(2), 403-411 (1994-05-13)
Alpidem, 6-chloro-2-(4-chlorophenyl)-N,N-dipropylimidazo[1,2-a]pyridine- 3-acetamide, is an anxiolytic imidazopyridine that undergoes a first-pass elimination after oral administration to humans; it is actively metabolized and three circulating metabolites have been identified in plasma due to N-dealkylation, oxidation or a combination of both processes.
M Hascoët et al.
Pharmacology, biochemistry, and behavior, 56(2), 317-324 (1997-02-01)
A comparative study between two drugs acting on the GABAA receptor, alprazolam and alpidem was undertaken, using simple tests such as measurement of spontaneous locomotor activity, four plates test and rotarod in mice. Additional conflict test was further performed using

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