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Merck
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N5536

Sigma-Aldrich

Nefazodone hydrochloride

≥98% (HPLC), solid, antidepressant

Sinónimos:

2-[3-[4-(3-chlorophenyl)-1-piperazinyl]propyl]-5-ethyl- 2,4-dihydro-4-(2-phenoxyethyl)-3H-1,2,4-triazol-3-one hydrochloride, BMY-13754, MJ-13754-1, Serzone

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About This Item

Fórmula empírica (notación de Hill):
C25H32ClN5O2 · HCl
Número de CAS:
82752-99-6
Peso molecular:
506.47
Número MDL:
MFCD00935760
Código UNSPSC:
12352200
ID de la sustancia en PubChem:
24724551
NACRES:
NA.77

product name

Nefazodone hydrochloride, ≥98% (HPLC), solid

Análisis

≥98% (HPLC)

formulario

solid

condiciones de almacenamiento

desiccated

color

white

solubilidad

DMSO: ≥10 mg/mL
H2O: insoluble

emisor

Bristol-Myers Squibb

cadena SMILES

O=C1N(CCCN2CCN(C3=CC=CC(Cl)=C3)CC2)N=C(CC)N1CCOC4=CC=CC=C4.Cl

InChI

1S/C25H32ClN5O2.ClH/c1-2-24-27-31(25(32)30(24)18-19-33-23-10-4-3-5-11-23)13-7-12-28-14-16-29(17-15-28)22-9-6-8-21(26)20-22;/h3-6,8-11,20H,2,7,12-19H2,1H3;1H

Clave InChI

DYCKFEBIOUQECE-UHFFFAOYSA-N

Información sobre el gen

human ... HTR2A(3356) , HTR2C(3358) , SLC6A2(6530) , SLC6A4(6532)

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Acciones bioquímicas o fisiológicas

Novel antidepressant; mixed 5-HT2A serotonin receptor antagonist/serotonin uptake inhibitor.

Características y beneficios

This compound was developed by Bristol-Myers Squibb. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Código de clase de almacenamiento

11 - Combustible Solids

Clase de riesgo para el agua (WGK)

WGK 3

Punto de inflamabilidad (°F)

Not applicable

Punto de inflamabilidad (°C)

Not applicable

Equipo de protección personal

Eyeshields, Gloves, type N95 (US)

Certificados de análisis (COA)

Busque Certificados de análisis (COA) introduciendo el número de lote del producto. Los números de lote se encuentran en la etiqueta del producto después de las palabras «Lot» o «Batch»

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S C Collins et al.
Diabetologia, 51(9), 1689-1693 (2008-07-16)
Long-term exposure to NEFAs leads to inhibition of glucose-induced insulin secretion. We tested whether the release of somatostatin and glucagon, the two other major islet hormones, is also affected. Mouse pancreatic islets were cultured for 72 h at 4.5 or
Jonathan N Bauman et al.
Drug metabolism and disposition: the biological fate of chemicals, 36(6), 1016-1029 (2008-03-12)
In vitro metabolism/bioactivation of structurally related central nervous system agents nefazodone (hepatotoxin) and aripiprazole (nonhepatotoxin) were undertaken in human liver microsomes in an attempt to understand the differences in toxicological profile. NADPH-supplemented microsomal incubations of nefazodone and glutathione generated conjugates
James A Dykens et al.
Toxicological sciences : an official journal of the Society of Toxicology, 103(2), 335-345 (2008-03-18)
Mitochondrial toxicity is increasingly implicated in a host of drug-induced organ toxicities, including hepatotoxicity. Nefazodone was withdrawn from the U.S. market in 2004 due to hepatotoxicity. Accordingly, we evaluated nefazodone, another triazolopyridine trazodone, plus the azaspirodecanedione buspirone, for cytotoxicity and
James H Kocsis et al.
The Journal of clinical psychiatry, 70(3), 354-361 (2009-02-05)
Little is known about moderators of response to psychotherapy, medication, and combined treatment for chronic forms of major depressive disorder (MDD). We hypothesized that patient preference at baseline would interact with treatment group to differentially affect treatment outcome. We report
Niklaus Stulz et al.
Journal of consulting and clinical psychology, 78(3), 409-419 (2010-06-03)
Psychotherapy-pharmacotherapy combinations are frequently recommended for the treatment of chronic depressive disorders. Our aim in this novel reanalysis of archival data was to identify patient subgroups on the basis of symptom trajectories and examine the clinical significance of the resultant
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