Following reconstitution at 25 mg/mL in 0.1 M Acetic acid, aliquot and freeze at -20°C. Stock solutions are stable for up to 3 months at -20°C. The stability of dilute solutions has not been determined, however, Bradykinin fragment 1 - 7, (B4181) is part of a set of standards for Maldi-MS calibration (MSCAL1). In this application, the solution is diluted to 10 pmol/uL and stored at -20°C for 1 month. One may infer that dilute solutions of the whole molecule would be comparably stable when diluted and stored frozen.
B3259
Bradykinin acetate salt
≥98% (HPLC), Ca2+-dependent nitric oxide synthetase activator, powder
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Fórmula empírica (notación de Hill):
C50H73N15O11 · xC2H4O2
Número CAS:
Peso molecular:
1060.21 (free base basis)
MDL number:
UNSPSC Code:
12352106
EC Number:
227-781-2
NACRES:
NA.32
Assay:
≥98% (HPLC)
Form:
powder
Solubility:
0.1 M acetic acid: 25 mg/mL, clear, colorless
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Permítanos ayudarleNombre del producto
Bradykinin acetate salt, powder, ≥98% (HPLC)
Quality Level
assay
≥98% (HPLC)
form
powder
storage condition
desiccated
color
white
solubility
0.1 M acetic acid: 25 mg/mL, clear, colorless
UniProt accession no.
storage temp.
−20°C
SMILES string
N2([C@@H](CCC2)C(=O)NCC(=O)N[C@@H](Cc5ccccc5)C(=O)N[C@@H](CO)C(=O)N3[C@@H](CCC3)C(=O)N[C@@H](Cc4ccccc4)C(=O)N[C@@H](CCCN=C(N)N)C(=O)O)C(=O)[C@H]1N(CCC1)C(=O)[C@@H](N)CCCN=C(N)N
InChI
1S/C50H73N15O11/c51-32(16-7-21-56-49(52)53)45(72)65-25-11-20-39(65)47(74)64-24-9-18-37(64)43(70)58-28-40(67)59-34(26-30-12-3-1-4-13-30)41(68)62-36(29-66)46(73)63-23-10-19-38(63)44(71)61-35(27-31-14-5-2-6-15-31)42(69)60-33(48(75)76)17-8-22-57-50(54)55/h1-6,12-15,32-39,66H,7-11,16-29,51H2,(H,58,70)(H,59,67)(H,60,69)(H,61,71)(H,62,68)(H,75,76)(H4,52,53,56)(H4,54,55,57)/t32-,33-,34-,35-,36-,37-,38-,39-/m0/s1
InChI key
QXZGBUJJYSLZLT-FDISYFBBSA-N
Gene Information
human ... KNG1 (includes EG:3827)
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1 of 4
Este artículo | |||
|---|---|---|---|
| form powder | form powder | form powder | form powder |
| solubility 0.1 M acetic acid: 25 mg/mL, clear, colorless | solubility acetic acid: 50 mg/mL, clear, colorless to very faintly yellow | solubility 50% acetic acid: 1 mg/mL, clear, colorless | solubility acetic acid: 10 mg/mL, clear, colorless to faintly yellow |
| assay ≥98% (HPLC) | assay ≥98% (HPLC) | assay ≥98% | assay ≥98% (TLC) |
| Quality Level 100 | Quality Level 200 | Quality Level 200 | Quality Level 200 |
| storage condition desiccated | storage condition - | storage condition - | storage condition - |
| color white | color - | color - | color - |
Application
Bradykinin acetate salt has been used:
- to stimulate the contraction of guinea pig ileum
- as a contractile agent in fibroblasts
- In the stimulation of endothelium of human subcutaneous artery
- To evoke Ca2+ signals in neuroblastoma-glioma hybrid cell line, NG108-15
Biochem/physiol Actions
Activates pain receptors; induces smooth muscle contraction; activates Ca2+-dependent nitric oxide synthetase; increases capillary permeability.
Bradykinin is a pro-inflammatory peptide that acts through G-protein-coupled receptors. It activates sphingolipid metabolism. Fibroblasts treated with bradykinin produce a rapid and important increase in ceramide which is followed by a transient rise in sphingosine content. The peptide also increases ceramide cellular content by rapidly mobilizing neutral glycolipids. Bradykinin plays an important role in the regulation of fluid and electrolyte balance, smooth muscle contraction, vasodilation and capillary permeability. The bradykinin potentiators, which possess no bradykinin activity themselves, enhance the activity of bradykinin.
Clase de almacenamiento
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
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How should a solution of bradykinin acetate salt in 0.1M acetic acid be stored? Can it be further diluted in an aqueous buffer?
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