C4382

Carbamoylcholine chloride

≥98% (titration), crystalline

• Sinónimos: (2-Hydroxyethyl)trimethylammonium chloride carbamate, Carbachol, Carbamylcholine chloride
• Fórmula lineal: NH₂COOCH₂CH₂N(Cl)(CH₃)₃
• Número de CAS: 51-83-2
• Peso molecular: 182.65
• Beilstein: 3917459
• Número CE: 200-127-3
• Número MDL: MFCD00012011
• Código UNSPSC: 12352200
• ID de la sustancia en PubChem: 24277829
• NACRES: NA.77

Propiedades

• Nivel de calidad: 100
• Ensayo: ≥98% (titration)
• Formulario: crystalline
• color: white
• mp: 210 °C (dec.) (lit.)
• solubilidad: H₂O: 1 g/mL; ethanol: 20 mg/mL
• cadena SMILES: [Cl-].C[N+](C)(C)CCOC(N)=O
• InChI: 1S/C6H14N2O2.ClH/c1-8(2,3)4-5-10-6(7)9;/h4-5H2,1-3H3,(H-,7,9);1H
• Clave InChI: AIXAANGOTKPUOY-UHFFFAOYSA-N
• Información sobre el gen: human ... CHRM1(1128) , CHRM2(1129) , CHRM3(1131) , CHRM4(1132) , CHRM5(1133) , CHRNA2(1135) ; mouse ... Chrm1(12669) ; rat ... Chrm1(25229) , Chrm2(81645) , Chrm3(24260) , Chrna2(170945) , Chrna3(25101) , Chrna4(25590)

Descripción

Aplicación

Carbamoylcholine chloride has been used:

• to stimulate insulin secretion in transgenic mice[1]
• to induce contraction of undifferentiated and differentiated human adipose-derived stem cells (hASCs)[2]
• to mediate constriction of iris in pupillary light reflex studies in mice[3]

Acciones bioquímicas o fisiológicas

Carbachol elicits tear fluid secretion by interacting with muscarinic receptors.[4] It is an analog of acetylcholine and an antiglaucoma drug. In ciliary processes, carbachol along with nitric oxide (NO) regulates Na⁺ and K⁺-ATPase activity.[5] It stimulates insulin vesicles transport to the secretory site to increase insulin secretion.[1]

Non-selective cholinergic agonist that is resistant to the action of cholinesterases; inhibits apoptotic death of cultured neurons, and may induce apoptosis in thymocytes.

Características y beneficios

This compound is featured on the Acetylcholine Receptors (Nicotinic) page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Información de seguridad

• Pictogramas: GHS06
• Palabra de señalización: Danger
• Frases de peligro: H300
• Consejos de prudencia: P264 - P270 - P301 + P310 - P405 - P501
• Clasificaciones de peligro: Acute Tox. 2 Oral
• Código de clase de almacenamiento: 6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials
• Clase de riesgo para el agua (WGK): WGK 3
• Punto de inflamabilidad (°F): Not applicable
• Punto de inflamabilidad (°C): Not applicable
• Equipo de protección personal: Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges