860815P

16:0(2R-OH) Ceramide

Avanti Research^™ - A Croda Brand 860815P, powder

• Sinónimos: N-(2′-(R)-hydroxypalmitoyl)-D-erythro-sphingosine
• Fórmula empírica (notación de Hill): C₃₄H₆₇NO₄
• Número de CAS: 34839-02-6
• Peso molecular: 553.90
• Número MDL: MFCD22416671
• Código UNSPSC: 12352211
• NACRES: NA.25

Propiedades

• Formulario: powder
• envase: pkg of 1 × 25 mg (860815P-25mg); pkg of 1 × 5 mg (860815P-5mg)
• fabricante / nombre comercial: Avanti Research^™ - A Croda Brand 860815P
• tipo de lípido: sphingolipids
• Condiciones de envío: dry ice
• temp. de almacenamiento: −20°C
• cadena SMILES: CCCCCCCCCCCCC/C=C/[C@@H](O)[C@@H](NC([C@H](O)CCCCCCCCCCCCCC)=O)CO
• Clave InChI: YWZGQPJRQXHVQX-GGMPIESISA-N

Descripción

Descripción general

Ceramides with 2-hydroxy fatty acids (hFA) group are present in the epidermis.[1] 16:0(2R-OH) Ceramide is a unique ceramide containing 16C long chain base fatty acid (palmitic acid)-with 2′-hydroxyl group in R configuration.[2]

Acciones bioquímicas o fisiológicas

Hydroxy fatty acid (hFA)-sphingolipids are implicated in cell signaling.[3] They may also help in regulation of cell differentiation and apoptosis. Synthetic 2′R-hydroxy-C16-ceramide exhibits high proapoptotic activity than proapoptotic 2′S-hydroxy-C16-ceramide.[2] hFA-ceramides in epidermis support permeability barrier function. hFA-ceramides are synthesized by fatty acid 2-hydroxylase (FA2H). Mutations of FA2H causes neurological disorders including, leukodystrophy and spastic paraparesis in humans.[3] The mechanism of action for an antitumor drug, PM02734 involves hFA-ceramides in the cell membrane.[4]

Envase

5 mL Amber Glass Screw Cap Vial (860815P-25mg)

5 mL Amber Glass Screw Cap Vial (860815P-5mg)

Información legal

Avanti Research is a trademark of Avanti Polar Lipids, LLC

Información de seguridad

• Código de clase de almacenamiento: 11 - Combustible Solids
• Clase de riesgo para el agua (WGK): WGK 3