SCP0170

Granulocyte Elastase Substrate human

≥95% (HPLC), lyophilized

• Empirische Formel (Hill-System): C₂₁H₂₇N₅O₆
• Molekulargewicht: 445.47
• UNSPSC-Code: 12352204
• NACRES: NA.32

Eigenschaften

• Produktbezeichnung: Granulocyte Elastase Substrate human,
• Assay: ≥95% (HPLC)
• Form: lyophilized
• Zusammensetzung: Peptide Content, ≥85%
• Lagerbedingungen: protect from light
• Lagertemp.: −20°C

Beschreibung

Amino Acid Sequence

Glp-Pro-Val-pNA

Allgemeine Beschreibung

Elastase, a glycoprotein, is a member of the serine proteases family.[1] It is synthesized by human polymorphonuclear (PMN) leukocytes or by the pancreas.[2] Human granulocyte elastase is liberated in large amounts from granulocytes in chronic inflammatory joint disorders.[3]

Biochem./physiol. Wirkung

Elastase is a catalytic enzyme that catalyzes the cleavage of carboxyl groups on tiny hydrophobic amino acids including glycine, alanine, and valine. Its main function is to break down elastin.[4] Free elastase in some purulent synovial fluids plays a key role in articular cartilage breakdown. Increased elastase levels in the plasma have been seen in patients with evident rheumatoid arthritis.[3]

Elastase(s) can be assayed and differentiated using chromogenic and fluorogenic Pro-Val peptide substrates such as Glp-Pro-Val-pNA and MeOSuc-Ala-Ala-Pro-Val-4-MNA.

Sicherheitshinweise

• Lagerklassenschlüssel: 11 - Combustible Solids
• WGK: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable