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M9771

Sigma-Aldrich

N-Methoxysuccinyl-Ala-Ala-Pro-Val-7-amido-4-methylcoumarin

elastase substrate

Synonym(e):

MeOSuc-AAPV-AMC

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383,00 €
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Versandbereit am07. April 2025Details


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5 MG
383,00 €
50 MG
1.640,00 €

About This Item

Empirische Formel (Hill-System):
C31H41N5O9
CAS-Nummer:
Molekulargewicht:
627.69
MDL-Nummer:
UNSPSC-Code:
12352204
PubChem Substanz-ID:
NACRES:
NA.32

383,00 €


Versandbereit am07. April 2025Details


Bulk-Bestellung anfordern

Assay

≥98% (HPLC)

Form

powder

Löslichkeit

chloroform: 50 mg/mL, clear, colorless

Lagertemp.

−20°C

SMILES String

COC(=O)CCC(=O)NC(C)C(=O)NC(C)C(=O)N1CCCC1C(=O)NC(C(C)C)C(=O)Nc2ccc3C(C)=CC(=O)Oc3c2

InChI

1S/C31H41N5O9/c1-16(2)27(30(42)34-20-9-10-21-17(3)14-26(39)45-23(21)15-20)35-29(41)22-8-7-13-36(22)31(43)19(5)33-28(40)18(4)32-24(37)11-12-25(38)44-6/h9-10,14-16,18-19,22,27H,7-8,11-13H2,1-6H3,(H,32,37)(H,33,40)(H,34,42)(H,35,41)

InChIKey

CMEUDEVBFFPSEI-UHFFFAOYSA-N

Anwendung

N-Methoxysuccinyl-Ala-Ala-Pro-Val-7-amido-4-methylcoumarin has been used as a substrate in elastase assay[1] using bone marrow lysates[2] and pancreatic lysates.[3]

Verpackung

Bottomless glass bottle. Contents are inside inserted fused cone.

Substrate

Fluorogenic substrate for the assay of human leukocyte and porcine pancreatic elastase.

Lagerklassenschlüssel

11 - Combustible Solids

WGK

WGK 3

Flammpunkt (°F)

Not applicable

Flammpunkt (°C)

Not applicable

Persönliche Schutzausrüstung

Eyeshields, Gloves, type N95 (US)


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Die Dokumentenbibliothek aufrufen

Teresa I Ng et al.
Antimicrobial agents and chemotherapy, 62(1) (2017-11-01)
Glecaprevir (formerly ABT-493) is a novel hepatitis C virus (HCV) NS3/4A protease inhibitor (PI) with pangenotypic activity. It inhibited the enzymatic activity of purified NS3/4A proteases from HCV genotypes 1 to 6 in vitro (half-maximal [50%] inhibitory concentration = 3.5
Sensitive substrates for human leukocyte and porcine pancreatic elastase: a study of the merits of various chromophoric and fluorogenic leaving groups in assays for serine proteases.
M J Castillo et al.
Analytical biochemistry, 99(1), 53-64 (1979-10-15)
Gerrit Wolters-Eisfeld et al.
Experimental & molecular medicine, 50(10), 1-13 (2018-10-12)
Cosmc is ubiquitously expressed and acts as a specific molecular chaperone assisting the folding and stability of core 1 synthase. Thus, it plays a crucial role in the biosynthesis of O-linked glycosylation of proteins. Here, we show that ablation of
Jonas Hahn et al.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 33(1), 1401-1414 (2018-08-22)
Papillon-Lefèvre syndrome (PLS) is characterized by nonfunctional neutrophil serine proteases (NSPs) and fulminant periodontal inflammation of unknown cause. Here we investigated neutrophil extracellular trap (NET)-associated aggregation and cytokine/chemokine-release/degradation by normal and NSP-deficient human and mouse granulocytes. Stimulated with solid or
D Polacek et al.
The Journal of biological chemistry, 261(5), 2057-2063 (1986-02-15)
In vitro incubation of human plasma low density lipoproteins (LDL) with human blood polymorphonuclear cells (PMN) for 1 h at 37 degrees C resulted in an increased (2-4-fold) release into the medium of an enzymatic activity which co-eluted with LDL

Artikel

Elastase application index for understanding leukocyte elastase, a 29KDa serine endoprotease.

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