M0398

N-(Methoxysuccinyl)-Ala-Ala-Pro-Val-Chlormethylketon

elastase inhibitor, powder, ≥98% (TLC)

• Synonym(e): N-(Methoxysuccinyl)-L-alanyl-L-alanyl-L-prolyl-L-valin-chlormethylketon
• Empirische Formel (Hill-System): C₂₂H₃₅ClN₄O₇
• CAS-Nummer: 65144-34-5
• Molekulargewicht: 502.99
• Beilstein: 6167019
• MDL-Nummer: MFCD00077136
• UNSPSC-Code: 12352202
• PubChem Substanz-ID: 24896552
• NACRES: NA.77

Eigenschaften

• Produktbezeichnung: N-(Methoxysuccinyl)-Ala-Ala-Pro-Val-Chlormethylketon, elastase inhibitor
• Assay: ≥98% (TLC)
• Form: powder
• mp (Schmelzpunkt): 159 °C
• Löslichkeit: methanol: 50 mg/mL, clear, colorless
• Lagertemp.: −20°C
• SMILES String: COC(=O)CCC(=O)N[C@@H](C)C(=O)N[C@@H](C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C(C)C)C(=O)CCl
• InChI: 1S/C22H35ClN4O7/c1-12(2)19(16(28)11-23)26-21(32)15-7-6-10-27(15)22(33)14(4)25-20(31)13(3)24-17(29)8-9-18(30)34-5/h12-15,19H,6-11H2,1-5H3,(H,24,29)(H,25,31)(H,26,32)/t13-,14-,15-,19-/m0/s1
• InChIKey: PJGDFLJMBAYGGC-XLPNERPQSA-N

Beschreibung

Allgemeine Beschreibung

N-(Methoxysuccinyl)-Ala-Ala-Pro-Val-chloromethyl ketone is a tetrapeptide, cell-permeable and non-cytotoxic inhibitor.[1]

Anwendung

N-(Methoxysuccinyl)-Ala-Ala-Pro-Val-chloromethyl ketone has been used as an elastase specific inhibitor.[2][3]

Biochem./physiol. Wirkung

N-(Methoxysuccinyl)-Ala-Ala-Pro-Val-chloromethyl ketone acts as a competitive inhibitor of human leukocyte elastase (HLE).[1]

Irreversible inhibitor of human leukocyte[4] and neutrophil[5] elastase.

Sicherheitshinweise

• Lagerklassenschlüssel: 11 - Combustible Solids
• WGK: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable
• Persönliche Schutzausrüstung: Eyeshields, Gloves, type N95 (US)