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F7751

Sigma-Aldrich

Fluoxymesteron

solid (photosensitive)

Synonym(e):

9α-Fluor-11β,17β-dihydroxy-17α-methylandrost-4-en-3-on, 9α-Fluor-11β-hydroxy-17α-methyltestosteron

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About This Item

Empirische Formel (Hill-System):
C20H29FO3
CAS-Nummer:
Molekulargewicht:
336.44
EG-Nummer:
MDL-Nummer:
UNSPSC-Code:
51111800
PubChem Substanz-ID:

Biologische Quelle

Porcine pancreas
bovine milk (other parts like skeletal muscle/bile/bone/connective tissue/skin)
microbial (Mycobacterium sp.)

Form

solid (photosensitive)

Arzneimittelkontrolle

USDEA Schedule III; Home Office Schedule 4.2; regulated under CDSA - not available from Sigma-Aldrich Canada

Methode(n)

HPLC: suitable
gas chromatography (GC): suitable

Farbe

white

Löslichkeit

H2O: ≤0.5 mg/mL
45% (w/v) aq 2-hydroxypropyl-β-cyclodextrin: 6.4 mg/mL
ethanol: 7.3 mg/mL

Anwendung(en)

forensics and toxicology
veterinary

Versandbedingung

ambient

Lagertemp.

room temp

SMILES String

[H][C@@]12CC[C@](C)(O)[C@@]1(C)C[C@H](O)[C@@]3(F)[C@@]2([H])CCC4=CC(=O)CC[C@]34C

InChI

1S/C20H29FO3/c1-17-8-6-13(22)10-12(17)4-5-15-14-7-9-19(3,24)18(14,2)11-16(23)20(15,17)21/h10,14-16,23-24H,4-9,11H2,1-3H3/t14-,15-,16-,17-,18-,19-,20-/m0/s1

InChIKey

YLRFCQOZQXIBAB-RBZZARIASA-N

Angaben zum Gen

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Biochem./physiol. Wirkung

androgen

Piktogramme

Health hazard

Signalwort

Warning

H-Sätze

P-Sätze

Gefahreneinstufungen

Repr. 2

Lagerklassenschlüssel

13 - Non Combustible Solids

WGK

WGK 3

Flammpunkt (°F)

Not applicable

Flammpunkt (°C)

Not applicable

Persönliche Schutzausrüstung

Eyeshields, Gloves, type P3 (EN 143) respirator cartridges


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C Rose et al.
Breast cancer research and treatment, 61(2), 103-110 (2000-08-15)
The efficacy of combined endocrine therapy with tamoxifen (TAM), aminoglutethimide (AG), and hydrocortisone (H) or tamoxifen and fluoxymesterone (FLU) was evaluated against treatment with tamoxifen alone in 311 patients above 65 years of age with a first recurrence of a
Farshid Rayhan et al.
Scientific reports, 7(1), 17731-17731 (2017-12-20)
Prediction of new drug-target interactions is critically important as it can lead the researchers to find new uses for old drugs and to disclose their therapeutic profiles or side effects. However, experimental prediction of drug-target interactions is expensive and time-consuming.
Oscar J Pozo et al.
Journal of mass spectrometry : JMS, 43(3), 394-408 (2007-11-27)
The suitability of liquid chromatography tandem mass spectrometry (LC-MS/MS) and gas chromatography mass spectrometry (GC-MS) for the elucidation of fluoxymesterone metabolism has been evaluated. Electrospray ionization (ESI) and collision induced dissociation (CID) fragmentation in LC-MS/MS and electron impact spectra (EI)
S M Stanley et al.
Journal of chromatography. B, Biomedical sciences and applications, 704(1-2), 119-128 (1998-03-28)
In this study the equine metabolism of fluoxymesterone (9alpha-fluoro-11beta-17beta-dihydroxy-17alpha-meth ylandrost-4-ene-3-one) given orally has been investigated. The parent material was not detected, but two major 16-hydroxy metabolites which corresponded to a mono- and a di-hydroxylation product were evident. One of the
J Aisner et al.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 13(6), 1443-1452 (1995-06-01)
We sought to compare three doxorubicin-based therapies for metastatic breast cancer for response frequency, time to treatment failure (TTF), and survival. Women with metastatic breast cancer who had measurable disease, required laboratory tests, had received no prior chemotherapy for metastases

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