E6627

cis-5,8,11,14,17-Eicosapentaenoic acid sodium salt

≥99% (capillary GC)

• Lineare Formel: CH₃(CH₂CH=CH)₅(CH₂)₃CO₂Na
• CAS-Nummer: 73167-03-0
• Molekulargewicht: 324.43
• MDL-Nummer: MFCD00079184
• UNSPSC-Code: 12352211
• PubChem Substanz-ID: 24894631
• NACRES: NA.77

Eigenschaften

• Biologische Quelle: synthetic (organic)
• Qualitätsniveau: 200
• Assay: ≥99% (capillary GC)
• Form: film or powder
• Farbe: white to off-white
• Löslichkeit: methanol: 50 mg/mL, clear to slightly hazy, colorless to faintly yellow
• Versandbedingung: dry ice
• Lagertemp.: −20°C
• SMILES String: [Na].CC\C=C/C\C=C/C\C=C/C\C=C/C\C=C/CCCC(O)=O
• InChI: 1S/C20H30O2.Na.H/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20(21)22;;/h3-4,6-7,9-10,12-13,15-16H,2,5,8,11,14,17-19H2,1H3,(H,21,22);;/b4-3-,7-6-,10-9-,13-12-,16-15-;;
• InChIKey: TVEGTERCKGGVCJ-LIJGWLRISA-N
• Angaben zum Gen: human ... ALOX5(240) ; mouse ... ALOX5(11689) ; rat ... ALOX5(25290)

Beschreibung

Allgemeine Beschreibung

Eicosapentaenoic acid (EPA)/timnodonic acid is an omega-3 polyunsaturated fatty acid (PUFA). This long-chain fatty acid is mainly found in fish oil.

Anwendung

cis-5,8,11,14,17-Eicosapentaenoic acid sodium salt has been used:

• to study its effect on the pathology of lupus in drug-induced and spontaneous mouse models
• to pretreat mouse alveolar macrophages to study the effect/relationship between amiodarone and eicosapentaenoic acid (EPA) concerning the cytokine release
• to examine if pharmacological correction with EPA supplementation might restore autophagic flux and reduce renal lipotoxicity in mice

Biochem./physiol. Wirkung

Eicosapentaenoic acid (EPA) possesses anti-hyperglycemic, anti-oxidant, anti-hyperlipidemic, and anti-inflammatory properties. It aids in improving vasoreactivity. EPA is capable of suppressing vascular smooth muscle proliferation. It ameliorates pulmonary hypertension by preventing Fyn kinase activity. EPA exhibits a beneficial effect on lipid metabolism. It is used to treat hypercholesterolemia and atherosclerosis.

5-Lipoxygenase inhibitor; reduces thromboxane A2 production.

Sicherheitshinweise

• Lagerklassenschlüssel: 11 - Combustible Solids
• WGK: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable
• Persönliche Schutzausrüstung: Eyeshields, Gloves, type N95 (US)