T2265

Tetraethylammonium chloride

≥98% (titration)

• Synonyma: TEA chloride
• Lineární vzorec: (C₂H₅)₄N(Cl)
• Číslo CAS: 56-34-8
• Molekulová hmotnost: 165.70
• Beilstein/REAXYS Number: 3563247
• EC Number: 200-267-5
• MDL number: MFCD00011828
• UNSPSC Code: 12352107
• PubChem Substance ID: 24277874
• NACRES: NA.32

Vlastnosti

• biological source: synthetic (organic)
• Quality Level: 200
• assay: ≥98% (titration)
• form: powder
• technique(s): blocking: suitable
• color: white to light yellow
• SMILES string: [Cl-].CC[N+](CC)(CC)CC
• InChI: 1S/C8H20N.ClH/c1-5-9(6-2,7-3)8-4;/h5-8H2,1-4H3;1H/q+1;/p-1
• InChI key: YMBCJWGVCUEGHA-UHFFFAOYSA-M
• Gene Information: human ... CHRNA1(1134) , CHRNA10(57053) , CHRNA2(1135) , CHRNA3(1136) , CHRNA4(1137) , CHRNA5(1138) , CHRNA6(8973) , CHRNA7(1139) , CHRNA9(55584) , CHRNB1(1140) , CHRNB2(1141) , CHRNB3(1142) , CHRNB4(1143)

Popis

application

Tetraethylammonium chloride (TEAC) has been used:

• used for inhibition of peroxynitrite induced relaxation in rat aorta rings[1]
• as a pharmacological blocker of K⁺ current and Ca²⁺ induced K⁺ current in antennal lobe neurons[2]
• for the induction of TEAC sensitive currents in cochlear inner hair cells digested with proteolytic enzymes and analyze its properties[3]

Biochem/physiol Actions

Blocks K⁺ channels; blocks nicotinic acetylcholine neurotransmission by blocking the receptor-mediated K⁺ currents.

Tetraethylammonium chloride (TEAC) blocks K⁺ channels non-specifically. In rat aorta rings, tetraethylammonium inhibits relaxation induced by peroxynitrite.[1] It blocks nicotinic acetylcholine neurotransmission by blocking the receptor-mediated K⁺ currents. TEAC can increase the contractility and mobility of colon and rectum and is a therapeutic option for Hirschsprung′s disease patients.[4] TEAC reduces the inflammatory responses, improves cardiac, vascular and hemodynamic properties during early sepsis in animals.[5] TEAC has cytotoxic and anti-proliferative potential and induces apoptosis in glioma cells by downregulating B-cell lymphoma-2 (Bcl-2) and upregulating Bcl-2 associated X (Bax).[6]

Caution

moisture sensitive, handle under argon

Other Notes

2024 CiteAb Award Winner for Supplier Succeeding in Parkinson′s Research

Bezpečnostní informace

• pictograms: GHS07
• signalword: Warning
• hcodes: H315,H319
• pcodes: P264 - P280 - P302 + P352 - P305 + P351 + P338 - P332 + P313 - P337 + P313
• Hazard Classifications: Eye Irrit. 2 - Skin Irrit. 2
• Storage Class: 11 - Combustible Solids
• wgk_germany: WGK 3
• flash_point_f: 201.2 °F - closed cup
• flash_point_c: 94 °C - closed cup
• ppe: dust mask type N95 (US), Eyeshields, Gloves