SML0187

CJ-13610

≥98% (HPLC)

• Synonyma: Tetrahydro-4-[3-[[4-(2-methyl-1H-imidazol-1-yl)phenyl]thio]phenyl]-2H-pyran-4-carboxamide
• Empirický vzorec (Hillův zápis): C₂₂H₂₃N₃O₂S
• Číslo CAS: 179420-17-8
• Molekulová hmotnost: 393.50
• MDL number: MFCD00948114
• UNSPSC Code: 51111800
• PubChem Substance ID: 329825216
• NACRES: NA.77

Vlastnosti

• Quality Level: 100
• assay: ≥98% (HPLC)
• form: powder
• storage condition: desiccated
• color: white to tan
• solubility: DMSO: ≥10 mg/mL
• storage temp.: 2-8°C
• SMILES string: Cc1nccn1-c2ccc(Sc3cccc(c3)C4(CCOCC4)C(N)=O)cc2
• InChI: 1S/C22H23N3O2S/c1-16-24-11-12-25(16)18-5-7-19(8-6-18)28-20-4-2-3-17(15-20)22(21(23)26)9-13-27-14-10-22/h2-8,11-12,15H,9-10,13-14H2,1H3,(H2,23,26)
• InChI key: VPTONMHDLLMOOV-UHFFFAOYSA-N

Popis

Application

CJ-13610 may be used to study 5-lipoxygenase-mediated cell signaling.

Biochem/physiol Actions

CJ-13,610 is a potent inhbititor of 5-lipoxygenase (5-LO) activity (IC₅₀ = 70 nM).

CJ-13610 inhibits the biosynthesis of leukotriene B4 and regulates the IL-6 mRNA expression in macrophages. It reduces fibrosis and necroinflammation of liver in carbon tetrachloride-treated mice.

Features and Benefits

This compound is featured on the Leukotriene Receptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Bezpečnostní informace

• Storage Class: 11 - Combustible Solids
• wgk_germany: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable