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SMB00424

Sigma-Aldrich

Platycodin D

≥98% (HPLC)

Synonyma:

3β-(β-D-glucopyranosyloxy)-2β,16α,23,24-tetrahydroxy-O-D-apio-β-D-furanosyl-(1→3)-O-β-D-xylopyranosyl-(1→4)-O-6-deoxy-olean-12-en-28-oic acid

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About This Item

Empirický vzorec (Hillův zápis):
C57H92O28
Číslo CAS:
58479-68-8
Molekulová hmotnost:
1225.32
UNSPSC Code:
12352205
PubChem Substance ID:
329825010
NACRES:
NA.25

Quality Level

200

assay

≥98% (HPLC)

form

powder

application(s)

metabolomics
vitamins, nutraceuticals, and natural products

storage temp.

2-8°C

SMILES string

O[C@@H]1[C@H](O[C@H]2[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O2)C(CO)(CO)[C@]3([H])CC[C@@]4(C)[C@]5(C)C[C@@H](O)[C@@]6(C(O[C@H]7[C@H](O[C@@H]8O[C@@H](C)[C@H](O[C@H]9[C@H](O)[C@@H](O[C@@H]%10OC[C@@](CO)(O)[C@H]%10O)[C@H](O)CO9)[C@@H](O)[C@H]8O)[C@@H](O)[C@@H](O

InChI

1S/C57H92O28/c1-23-40(81-45-39(72)41(30(64)18-76-45)82-49-43(73)56(75,21-61)22-78-49)36(69)38(71)46(79-23)83-42-33(66)29(63)17-77-48(42)85-50(74)57-12-11-51(2,3)14-27(57)24-7-9-52(4)26-13-28(62)44(84-47-37(70)35(68)34(67)31(16-58)80-47)55(19-59,20-60)25(26)8-10-54(52,6)53(24,5)15-32(57)65/h7,23,25-49,58-73,75H,8-22H2,1-6H3/t23-,25+,26-,27-,28-,29-,30+,31+,32+,33-,34+,35-,36-,37+,38+,39+,40-,41-,42+,43-,44-,45-,46-,47-,48?,49-,52+,53+,54+,56+,57+/m0/s1

InChI key

RJDYKSRQTBCKLC-XTIQGCOGSA-N

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General description

Platycodin D (PD) is a triterpenoid saponin found in the root of Platycodon grandifloras called Platycodonis Radix.

Application

Platycodin D has been used:
  • to test its anti-inflammatory and inhibitory effect on eosinophilic airway inflammation and T-helper type 2 (Th2) signaling pathways using ovalbumin (OVA)-induced allergic asthma mouse model
  • to test its anti-obese effects on the activation of brown adipose tissue featuring in vivo and in vitro studies
  • to test its efficacy as an adjuvant with infectious bronchitis (IB) vaccine in chicken

Biochem/physiol Actions

Platycodin D elicits strong anti-cancer properties and exhibits cytotoxicity against several cancer cell lines of both in vitro and in vivo origin. It exerts anti-inflammatory and protective effects against lipopolysaccharide (LPS)-induced acute lung injury (ALI) by upregulating liver-X receptors α (LXRα) and ATP-binding cassette transporter A1 (ABCA1) signaling pathway. It also possesses protective effects against Cisplatin (CDDP)-induced nephrotoxicity in mice.

pictograms

Exclamation mark
GHS07

signalword

Warning

hcodes

H302

Hazard Classifications

Acute Tox. 4 Oral

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

Osvědčení o analýze (COA)

Vyhledejte osvědčení Osvědčení o analýze (COA) zadáním čísla šarže/dávky těchto produktů. Čísla šarže a dávky lze nalézt na štítku produktu za slovy „Lot“ nebo „Batch“.

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Eung Gu Lee et al.
The Journal of asthma : official journal of the Association for the Care of Asthma, 1-11 (2021-06-16)
Introduction: Bronchial asthma is a common chronic inflammatory condition of the airway tissue. Platycodin D (PLD) has antiinflammatory effects in a mouse model of allergic asthma. In this work, the anti-asthma potential of PLD was studied by investigation of its
Yefei Zhou et al.
The journal of poultry science, 57(2), 160-167 (2020-05-29)
Adjuvants are common vaccine components. Novel adjuvants may improve the protective immunity conferred by vaccines against poultry diseases. Here, a less-hemolytic saponin, platycodin D (PD), isolated from the root of Platycodon grandiflorum was investigated as a potential alternative adjuvant. PD
Tae-Won Kim et al.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, 50(12), 4254-4259 (2012-05-24)
Platycodin D (PD) is well known as a potent triterpenoid saponin having various pharmacological activities isolated from the root of Platycodon grandiflorum (Jacq.) A. DC. (Campanulaceae). We aimed to evaluate protective effect of PD on cisplatin (CDDP)-induced nephrotoxicity. Male ICR
J L Gajewski et al.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 7(11), 1637-1645 (1989-11-01)
One hundred ninety-six patients with acute myelogenous leukemia (AML) were treated with intensive induction chemotherapy using similar daunorubicin/cytarabine/thioguanine regimens. Treatment results of 44 patients who had a documented preleukemic syndrome or cytopenia present for more than 2 months before developing
Hye-Lin Kim et al.
Phytomedicine : international journal of phytotherapy and phytopharmacology, 52, 254-263 (2019-01-03)
Platycodi Radix (root of Platycodon grandiflorum) and its active compound platycodin D (PD) has been previously shown to possess anti-obesity properties, but the underlying mechanisms remain poorly understood. The present study was aimed to evaluate the anti-obese effect of PD
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