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S0693

Sigma-Aldrich

SB 204741

>98% (HPLC)

Synonyma:

N-(1-Methyl-1H-5-indolyl)-N′-(3-methyl-5-isothiazolyl)urea

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About This Item

Empirický vzorec (Hillův zápis):
C14H14N4OS
Číslo CAS:
152239-46-8
Molekulová hmotnost:
286.35
MDL number:
MFCD00923644
UNSPSC Code:
12352200
PubChem Substance ID:
24278321
NACRES:
NA.77

Quality Level

100

assay

>98% (HPLC)

form

solid

color

off-white to tan

solubility

DMSO: soluble >20 mg/mL

originator

GlaxoSmithKline

storage temp.

2-8°C

SMILES string

Cc1cc(NC(=O)Nc2ccc3n(C)ccc3c2)sn1

InChI

1S/C14H14N4OS/c1-9-7-13(20-17-9)16-14(19)15-11-3-4-12-10(8-11)5-6-18(12)2/h3-8H,1-2H3,(H2,15,16,19)

InChI key

USFUFHFQWXDVMH-UHFFFAOYSA-N

Gene Information

human ... DRD2(1813) , DRD3(1814) , DRD5(1816) , HTR1E(3354) , HTR2A(3356) , HTR2B(3357) , HTR2C(3358)
rat ... Adra1a(29412) , Gabra2(29706) , Htr1a(24473) , Htr2b(29581) , Htr3a(79246)

Application

SB 204741 has been used as a 5-hydroxytryptamine receptor 2B (Htr2B) antagonist:
  • to inhibit Htr2b signaling to test its effect on hepatic stellate cell (HSC) activation in three-month-old adult zebrafish
  • to test its effect on the inhibition of fluoxetine effects in depressive-like behavioral studies in mice
  • to test its effect in reducing scratching behavior evoked by sertraline in mice

Biochem/physiol Actions

5-HT2B serotonin receptor antagonist.
SB 204741 reduces the synaptic facilitation induced by the low dose of buprenorphine in spinal C-fiber synapses.

Features and Benefits

This compound was developed by GlaxoSmithKline. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Legal Information

Sold for research purposes under agreement from Glaxo­Smith­Kline

pictograms

Exclamation mark
GHS07

signalword

Warning

Hazard Classifications

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

target_organs

Respiratory system

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Gloves

Vyberte jednu z posledních verzí:

Osvědčení o analýze (COA)

Lot/Batch Number
0000202536
0000236870
0000236870
0000202536
0000130637

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