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S0149

Sigma-Aldrich

Streptolysin O from Streptococcus pyogenes

γ-irradiated

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About This Item

Číslo CAS:
98072-47-0
EC Number:
308-500-3
MDL number:
MFCD00132389
UNSPSC Code:
12352200
NACRES:
NA.77

biological source

Streptococcus pyogenes

Quality Level

200

sterility

γ-irradiated

form

lyophilized powder

application(s)

cell analysis

storage temp.

2-8°C

Gene Information

Streptococcus pyogenes ... slo(900490)

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Application

Streptolysin O from Streptococcus pyogenes has been used in streptolysin O (SLO) permeabilization. It has also been used to evaluate the barrier integrity and cytotoxicity of caco-2 and T84 IEC polarized monolayers.
Permeabilizes membranes to permit cellular uptake of large or charged molecules.

Biochem/physiol Actions

Streptolysin O (SLO), obtained from Streptococcus pyogenes has the capability to block osteoclastogenesis, induced by receptor activator of nuclear factor κ-Β ligand (RANK) through the NF-κB signaling pathway. Streptococcus pyogenes (GAS) is a bacterial strain that results in bacterial arthritis, osteomyelitis and implant infections.
Thiol-activated toxin that permeabilizes animal cell membranes. The protein binds as a monomer to membrane cholesterol and subsequently polymerizes into large arc- and ring-shaped structures surrounding pores of >12 nm.

Unit Definition

One unit will cause 50% lysis of 2% red blood cell suspensions in phosphate buffered saline, pH 7.4, after incubation at 37 °C for 30 min.

Preparation Note

Prepared from S 5265

pictograms

Skull and crossbones
GHS06

signalword

Danger

Hazard Classifications

Acute Tox. 1 Dermal - Acute Tox. 1 Inhalation - Acute Tox. 1 Oral

Storage Class

6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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Osvědčení o analýze (COA)

Lot/Batch Number
0000214355
069M4140V
11181028
076M4070V
025M4060V

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Extended exposure duration of cultured intestinal epithelial cell monolayers in characterizing hazardous and non-hazardous proteins
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Streptolysin O derived from Streptococcus pyogenes inhibits RANKL-induced osteoclastogenesis through the NF-kappaB signaling pathway
Yi J, et al.
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