PZ0177

OSU6162 hydrochloride

≥98% (HPLC)

• Synonyma: PNU-96391; PNU-0096391; OSU-6162; (S)-(-)-(3-methanesulfonyl-phenyl)-1-propyl-piperidine hydrochloride; (S,S)-3-[3-(Methylsulfonyl)phenyl]-1-propylpiperidine hydrochloride
• Empirický vzorec (Hillův zápis): C₁₅H₂₃NO₂S·HCl
• Číslo CAS: 156907-84-5
• Molekulová hmotnost: 317.87
• MDL number: MFCD09753276
• UNSPSC Code: 51111800
• PubChem Substance ID: 329823751
• NACRES: NA.77

Vlastnosti

• assay: ≥98% (HPLC)
• form: powder
• optical activity: [α]/D -5 to -7°, c = 1 in methanol
• color: white to tan
• solubility: H₂O: ≥16 mg/mL
• storage temp.: −20°C
• SMILES string: Cl.CCCN1CCC[C@H](C1)c2cccc(c2)S(C)(=O)=O
• InChI: 1S/C15H23NO2S.ClH/c1-3-9-16-10-5-7-14(12-16)13-6-4-8-15(11-13)19(2,17)18;/h4,6,8,11,14H,3,5,7,9-10,12H2,1-2H3;1H/t14-;/m1./s1
• InChI key: LEMGVHZVBREXAD-PFEQFJNWSA-N

Popis

Biochem/physiol Actions

OSU6162 (PNU-96391) is a dopamine stabilizer, a drug that can stimulate or inhibit dopaminergic signaling depending on the dopaminergic tone. Dopaminergic stabilizers have been proposed to act as partial dopamine receptor agonists or as antagonists with both dopamine and behavioral stabilizing activity. Although affinity is not high (in vitro binding affinity for dopamine D2 receptor has a Ki of 447 nM), OSU6162 shows a high level of receptor occupancy.

OSU6162 is a dopamine stabilizer

Features and Benefits

This compound is featured on the Dopamine Receptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Legal Information

Sold for research purposes under agreement from Pfizer Inc.

Bezpečnostní informace

• pictograms: GHS07
• signalword: Warning
• hcodes: H302,H319
• pcodes: P264 - P280 - P301 + P312 - P305 + P351 + P338 - P337 + P313 - P501
• Hazard Classifications: Acute Tox. 4 Oral - Eye Irrit. 2
• Storage Class: 11 - Combustible Solids
• wgk_germany: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable