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N6037

Sigma-Aldrich

Neridronate

≥97% (NMR), solid, bone resorption inhibitor

Synonyma:

6-Amino-1-hydroxyhexylidene bisphosphonic acid, Neridronic acid, Nerixia

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About This Item

Empirický vzorec (Hillův zápis):
C6H17NO7P2
Číslo CAS:
79778-41-9
Molekulová hmotnost:
277.15
MDL number:
MFCD00866995
UNSPSC Code:
51111800
PubChem Substance ID:
24724553
NACRES:
NA.77

product name

Neridronate, ≥97% (NMR), solid

description

may contain <1% (w/w) inorganic salts

Quality Level

100

assay

≥97% (NMR)

form

solid

color

white

solubility

H2O: >5 mg/mL

storage temp.

2-8°C

SMILES string

NCCCCCC(O)(P(O)(O)=O)P(O)(O)=O

InChI

1S/C6H17NO7P2/c7-5-3-1-2-4-6(8,15(9,10)11)16(12,13)14/h8H,1-5,7H2,(H2,9,10,11)(H2,12,13,14)

Inchi Key

PUUSSSIBPPTKTP-UHFFFAOYSA-N

Biochem/physiol Actions

Neridronate is a bone resorption inhibitor. It is used to treat Osteogenesis Imperfecta, an "orphan disease" characterized by a fragility of the bone enough to be named the "illness of bones of crystal".

pictograms

Exclamation mark
GHS07

signalword

Warning

hcodes

H302

Hazard Classifications

Acute Tox. 4 Oral

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Gloves

Osvědčení o analýze (COA)

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Etidronate disodium hydrate &#8805;97% (NMR), solid

Sigma-Aldrich

P5248

Etidronate disodium hydrate

Alendronate Sodium Pharmaceutical Secondary Standard; Certified Reference Material

Supelco

PHR1599

Alendronate Sodium

Zoledronic acid monohydrate &#8805;98% (HPLC)

Sigma-Aldrich

SML0223

Zoledronic acid monohydrate

Zoledronic acid United States Pharmacopeia (USP) Reference Standard

USP

1724827

Zoledronic acid

Yasmina Hamdous et al.
Journal of nanobiotechnology, 15(1), 74-74 (2017-10-19)
Biologics magnetics nanoparticles, magnetosomes, attract attention because of their magnetic characteristics and potential applications. The aim of the present study was to develop and characterize novel magnetosomes, which were extracted from magnetotactic bacteria, purified to produce apyrogen magnetosome minerals, and
Patrizia D'Eufemia et al.
Pediatric research, 63(2), 203-206 (2007-12-20)
Prostaglandin E2 (PGE2) is an activator of bone remodeling, and increase levels of PGE2 are found in several disorders characterized by chronic inflammation. Bisphosphonates are used in the treatment of osteogenesis imperfecta (OI), an inherited disorder characterized by bone fragility
M Benucci et al.
Clinical and experimental rheumatology, 27(4), 567-573 (2009-09-24)
To assess the effects of intramuscular (im) neridronate (NE) on lumbar and femoral neck BMD and on markers of bone turnover in rheumatic patients under chronic low-dose glucocorticoids (GC) therapy. Sixty-nine osteopoenic and osteoporotic patients, affected by rheumatic diseases and
Silvano Adami et al.
Calcified tissue international, 83(5), 301-307 (2008-10-24)
Compliance to osteoporosis treatment with oral bisphosphonates is very poor. Intermittent intravenous bisphosphonate is a useful alternative, but this route is not readily available. Neridronate, a nitrogen-containing bisphosphonate that can be given intramuscularly (IM), was tested in a phase 2
Pietro Persiani et al.
Medicine, 96(20), e6766-e6766 (2017-05-18)
The purpose of this study is to compare the results of 2 techniques, tension band wiring (TBW) and fixation with screws, in olecranon fractures in children affected with osteogenesis imperfecta (OI) type I. Between 2010 and 2014, 21 olecranon fractures
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