C221

Carboxy-PTIO potassium salt

• Synonyma: 2-(4-Carboxyphenyl)-4,4,5,5-tetramethylimidazoline-1-oxyl-3-oxide potassium salt, 2-(4-Carboxyphenyl)-4,5-dihydro-4,4,5,5-tetramethyl-1H-imidazol-1-yloxy-3-oxide potassium salt
• Empirický vzorec (Hillův zápis): C₁₄H₁₆KN₂O₄
• Číslo CAS: 148819-94-7
• Molekulová hmotnost: 315.39
• MDL number: MFCD00216153
• UNSPSC Code: 12352200
• PubChem Substance ID: 24892474
• NACRES: NA.32

Vlastnosti

• biological source: synthetic (organic)
• Quality Level: 100
• assay: ≥98% (TLC)
• form: powder
• mp: >270 °C
• solubility: H₂O: 100 mg/mL; DMSO: soluble (lit.)(lit.); methanol: soluble (lit.)(lit.)
• storage temp.: 2-8°C
• SMILES string: [K+].CC1(C)N([O])C(c2ccc(cc2)C([O-])=O)=[N+]([O-])C1(C)C
• InChI: 1S/C14H17N2O4.K/c1-13(2)14(3,4)16(20)11(15(13)19)9-5-7-10(8-6-9)12(17)18;/h5-8H,1-4H3,(H,17,18);/q;+1/p-1
• InChI key: VYEUQMVIGXFZQU-UHFFFAOYSA-M

Popis

General description

2-(4-Carboxyphenyl)-4,4,5,5-tetramethylimidazoline-1-oxyl-3-oxide (carboxy-PTIO) is mainly considered as a scavenger of nitric oxide (NO).

Application

Carboxy-PTIO potassium salt has been used to check the generation of hydroxyl radicals or nitric in reaction mixtures to examine the generation of nitric oxide in reaction mixture. It has also been added to neurons to analyse its effect on glucose/oxygen/serum deprivation (GOSD) condition(4)

Biochem/physiol Actions

Carboxy-PTIO can make a quick reaction with nitric oxide (NO) to produce nitrogen dioxide (NO₂). It can be used to prevent hypotension and endotoxic shock, stimulated by lipopolysaccharide in- vivo. Carboxy-PTIO can also block in vitro vascular relaxation, stimulated by NO.

Reacts with nitric oxide to form carboxy-PTI derivatives which in turn inhibits nitric oxide synthase.

Bezpečnostní informace

• Storage Class: 11 - Combustible Solids
• wgk_germany: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable
• ppe: Eyeshields, Gloves, type N95 (US)