Přejít k obsahu
Merck
Všechny fotografie(1)

Key Documents

View All Documentation

07039

Sigma-Aldrich

(R)-(+)-α-Lipoic acid

≥98.0% (HPLC)

Synonyma:

(R)-(+)-1,2-Dithiolane-3-pentanoic acid, (R)-6,8-Dithiooctanoic acid, (R)-6,8-Thioctic acid

Přihlásitk zobrazení cen stanovených pro organizaci a smluvních cen
Všechny fotografie(1)

About This Item

Empirický vzorec (Hillův zápis):
C8H14O2S2
Číslo CAS:
1200-22-2
Molekulová hmotnost:
206.33
MDL number:
MFCD01631142
UNSPSC Code:
12352202
PubChem Substance ID:
329748332
NACRES:
NA.32

Quality Level

200

assay

≥98.0% (HPLC)

optical purity

enantiomeric excess: ≥98.0% (HPLC)

mp

48-52 °C (lit.)

storage temp.

−20°C

SMILES string

OC(=O)CCCC[C@@H]1CCSS1

InChI

1S/C8H14O2S2/c9-8(10)4-2-1-3-7-5-6-11-12-7/h7H,1-6H2,(H,9,10)/t7-/m1/s1

InChI key

AGBQKNBQESQNJD-SSDOTTSWSA-N

Hledáte podobné produkty? Navštivte Průvodce porovnáváním produktů

Biochem/physiol Actions

(R)-(+)-α-Lipoic acid was shown to significantly increase pyruvate oxidation while abrogating fatty acid oxidation in rat hepatocytes. These effects make R-(+)-α-Lipoic acid a promising treatment option for the treatment of Type II diabetes. It is a biological antioxidant with prooxidant activities, its therapeutic potential is widely investigated, e.g. in the treatment for Alzheimer′s disease.

Packaging

Bottomless glass bottle. Contents are inside inserted fused cone.

Analysis Note

identity confirmed by LC-MS

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

Osvědčení o analýze (COA)

Vyhledejte osvědčení Osvědčení o analýze (COA) zadáním čísla šarže/dávky těchto produktů. Čísla šarže a dávky lze nalézt na štítku produktu za slovy „Lot“ nebo „Batch“.

Již tento produkt vlastníte?

Dokumenty související s produkty, které jste v minulosti zakoupili, byly za účelem usnadnění shromážděny ve vaší Knihovně dokumentů.

Navštívit knihovnu dokumentů

Zákazníci si také prohlíželi

Slide 1 of 3

1 of 3

Thioctic acid containing impurity B European Pharmacopoeia (EP) Reference Standard

Y0000545

Thioctic acid containing impurity B

Valerian standardised dry extract European Pharmacopoeia (EP) Reference Standard

Y0000583

Valerian standardised dry extract

Parthenolide ≥98% (HPLC)

Sigma-Aldrich

P0667

Parthenolide

Jennie L Walgren et al.
Metabolism: clinical and experimental, 53(2), 165-173 (2004-02-10)
R-(+)-alpha-lipoic acid (R-LA) is the naturally occurring enantiomer of LA. It is a strong antioxidant and cofactor of key metabolic enzyme complexes catalyzing the decarboxylation of alpha-keto acids. Racemic LA (rac-LA) has shown promise in treating diabetic polyneuropathy, and some
Kate Petersen Shay et al.
Biochimica et biophysica acta, 1790(10), 1149-1160 (2009-08-12)
Alpha-lipoic acid (LA) has become a common ingredient in multivitamin formulas, anti-aging supplements, and even pet food. It is well-defined as a therapy for preventing diabetic polyneuropathies, and scavenges free radicals, chelates metals, and restores intracellular glutathione levels which otherwise
Annette Maczurek et al.
Advanced drug delivery reviews, 60(13-14), 1463-1470 (2008-07-29)
Alzheimer's disease (AD) is a progressive neurodegenerative disorder that destroys patient memory and cognition, communication ability with the social environment and the ability to carry out daily activities. Despite extensive research into the pathogenesis of AD, a neuroprotective treatment -
Dove J Keith et al.
Pharmacological research, 66(3), 199-206 (2012-05-23)
Lipoic acid (LA) shows promise as a beneficial micronutrient toward improving elder health. Studies using old rats show that (R)-α-LA (R-LA) significantly increases low molecular weight antioxidants that otherwise decline with age. Despite this rationale for benefiting human health, little
Takashi Yamada et al.
Neurochemistry international, 59(7), 1003-1009 (2011-10-13)
Growing evidence suggests that α-lipoic acid (LA) has neuroprotective effects in various pathological conditions including brain ischemia and neurodegeneration. While anti-oxidative activity has been thought to play a central role in LA-mediated neuroprotection, the precise mechanism and the effect of
Zobrazit všechny související dokumenty

Náš tým vědeckých pracovníků má zkušenosti ve všech oblastech výzkumu, včetně přírodních věd, materiálových věd, chemické syntézy, chromatografie, analytiky a mnoha dalších..

Obraťte se na technický servis.