G6529

L-Glutathione reduced

≥98.0%, BioXtra

• Synonyma: γ-L-Glutamyl-L-cysteinyl-glycine, GSH
• Lineární vzorec: H₂NCH(CO₂H)CH₂CH₂CONHCH(CH₂SH)CONHCH₂CO₂H
• Číslo CAS: 70-18-8
• Molekulová hmotnost: 307.32
• Beilstein/REAXYS Number: 1729812
• EC Number: 200-725-4
• MDL number: MFCD00065939
• UNSPSC Code: 12352209
• PubChem Substance ID: 24895261
• NACRES: NA.26

Vlastnosti

• Název produktu: L-Glutathione reduced, BioXtra, ≥98.0%
• product line: BioXtra
• Quality Level: 200
• assay: ≥98.0%
• form: powder
• impurities: ≤0.02% Phosphorus (P); ≤0.1% Insoluble matter
• ign. residue: ≤0.1%
• color: white
• mp: 192-195 °C (dec.) (lit.)
• solubility: H₂O: 0.1 M, clear, colorless
• anion traces: sulfate (SO₄^2-): ≤0.05%
• cation traces: Al: ≤0.0005%; Ca: ≤0.02%; Cu: ≤0.0005%; Fe: ≤0.001%; K: ≤0.005%; Mg: ≤0.001%; NH₄⁺: ≤0.05%; Na: ≤0.005%; Pb: ≤0.001%; Zn: ≤0.0005%
• storage temp.: 2-8°C
• SMILES string: N[C@@H](CCC(=O)N[C@@H](CS)C(=O)NCC(O)=O)C(O)=O
• InChI: 1S/C10H17N3O6S/c11-5(10(18)19)1-2-7(14)13-6(4-20)9(17)12-3-8(15)16/h5-6,20H,1-4,11H2,(H,12,17)(H,13,14)(H,15,16)(H,18,19)/t5-,6-/m0/s1
• InChI key: RWSXRVCMGQZWBV-WDSKDSINSA-N

Popis

Amino Acid Sequence

γ-Glu-Cys-Gly

Application

May be used at 5-10 mM to elute glutathione S-transferase (GST) from glutathione agarose.

Biochem/physiol Actions

Endogenous antioxidant that plays a major role in reducing reactive oxygen species formed during cellular metabolism and the respiratory burst. Glutathione-S-transferase catalyzes the formation of glutathione thioethers with xenobiotics, leukotrienes, and other molecules that have an electrophilic center. Glutathione also forms disulfide bonds with cysteine residues in proteins. Via these mechanisms, it can have the paradoxical effect of reducing the efficacy of anti-cancer agents.

Bezpečnostní informace

• Storage Class: 11 - Combustible Solids
• wgk_germany: WGK 2
• flash_point_f: Not applicable
• flash_point_c: Not applicable
• ppe: Eyeshields, Gloves, type N95 (US)