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Merck
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Key Documents

662141

Sigma-Aldrich

PR-619

≥99% (HPLC), solid, DUB inhibitor, Calbiochem®

Synonyma:

DUB Inhibitor V, PR-619, 2,6-Diaminopyridine-3,5-bis(thiocyanate), 3,5-Dithiocyanatopyridine-2,6-diamine, PR619, UCH-L1 Inhibitor IV, UCH-L3 Inhibitor II, UCH-L5/UCH37 Inhibitor III, USP5 Inhibitor II, USP7 Inhibitor I, USP9X Inhibitor II, USP14 Inhibitor IV, USP14 Inhibitor IV, USP47 Inhibitor I, UCH-L3 Inhibitor II, UCH-L5/UCH37 Inhibitor III, USP5 Inhibitor II, USP7 Inhibitor I, USP9X Inhibitor II, USP14 Inhibitor IV, USP14 Inhibitor IV, USP47 Inhibitor I, 2,6-Diaminopyridine-3,5-bis(thiocyanate), 3,5-Dithiocyanatopyridine-2,6-diamine, PR619, UC

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About This Item

Empirický vzorec (Hillův zápis):
C7H5N5S2
Molekulová hmotnost:
223.28
UNSPSC Code:
12352200
NACRES:
NA.77

product name

DUB Inhibitor V, PR-619, The DUB Inhibitor V, PR-619 controls the biological activity of DUB. This small molecule/inhibitor is primarily used for Protease Inhibitors applications.

Quality Level

100

assay

≥99% (HPLC)

form

solid

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze
protect from light

color

light beige to yellow

solubility

DMSO: 50 mg/mL

shipped in

ambient

storage temp.

2-8°C

General description

A cell-permeable pyridinamine class broad-spectrum DUB inhibitor whose known targets include ATXN3, BAP1, JOSD2, OTUD5, UCH-L1, UCH-L3, UCH-L5/UCH37, USP1, 2, 4, 5, 7, 8, 9X, 10, 14, 15, 16, 19, 20, 22, 24, 28, 47, 48, VCIP135, YOD1, as well as deISGylase PLpro, deNEDDylase DEN1, and deSUMOlyase SENP6. Both PR-619 and P22077 (Cat. No. 662142) are shown to increase overall protein polyubiquitination in HEK293T cells in a dose- and time-dependent manner (20 to 150 µM; 0.5 to 20 h), however P22077 exposure results in mainly enrichment of K48-linked, while PR619 treatment results in upregulation of both K48- and K63-linked polyUb chains.

Packaging

Packaged under inert gas

Warning

Toxicity: Standard Handling (A)

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

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International journal of molecular sciences, 23(14) (2022-07-28)
Rab7 is a GTPase that controls late endosome and lysosome trafficking. Recent studies have demonstrated that Rab7 is ubiquitinated, a post-translational modification mediated by an enzymatic cascade. To date, only one ubiquitin E3 ligase and one deubiquitinase have been identified
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Although most eukaryotic proteins are targeted for proteasomal degradation by ubiquitination, a subset have been demonstrated to undergo ubiquitin-independent proteasomal degradation (UbInPD). However, little is known about the molecular mechanisms driving UbInPD and the degrons involved. Utilizing the GPS-peptidome approach
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