567051-M

Sinefungin

InSolution, ≥95%, antibiotic

• Synonyma: InSolution Sinefungin, SF, Adenosyl-ornithine, A9145
• Empirický vzorec (Hillův zápis): C₁₅H₂₃N₇O₅
• Číslo CAS: 58944-73-3
• Molekulová hmotnost: 381.39
• MDL number: MFCD00865623
• UNSPSC Code: 12352200

Vlastnosti

• Quality Level: 100
• assay: ≥95% (HPLC)
• form: liquid
• manufacturer/tradename: Calbiochem^®
• storage condition: OK to freeze; protect from light
• storage temp.: −20°C
• SMILES string: [n]2(c3ncnc(c3nc2)N)[C@@H]1O[C@@H]([C@H]([C@H]1O)O)C[C@@H](N)CC[C@H](N)C(=O)O
• InChI: 1S/C15H23N7O5/c16-6(1-2-7(17)15(25)26)3-8-10(23)11(24)14(27-8)22-5-21-9-12(18)19-4-20-13(9)22/h4-8,10-11,14,23-24H,1-3,16-17H2,(H,25,26)(H2,18,19,20)/t6-,7-,8+,10+,11+,14+/m0/s1
• InChI key: LMXOHSDXUQEUSF-YECHIGJVSA-N

Popis

General description

An anti-leishmanial nucleoside antibiotic that acts as an S-adenosyl-L-methionine (SAM, AdoMet) methyltransferase-specific inhibitor.

Biochem/physiol Actions

Primary Target
S-adenosyl-L-methionine (SAM, AdoMet) methyltransferase

Warning

Toxicity: Standard Handling (A)

Physical form

A 10 mM (2 mg/524 µl) solution in H₂O.

Reconstitution

Following initial thaw, aliquot and freeze (-20°C).

Other Notes

Cheng, D., et al. 2004. J. Biol. Chem.279, 23892.
Lin, Q., et al. 2001. J. Am. Chem. Soc.123, 11608.
Zingg, J.M., et al. 1996. Nucleic Acids Res.24, 3267.
McCammon, M.T., and Parks, L.W. 1981. J. Bacteriol.145, 106.
Pugh, C.S.G., et al. 1978. J. Biol. Chem.253, 4075.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Bezpečnostní informace

• Storage Class: 11 - Combustible Solids
• wgk_germany: WGK 3