559276

Ryanodine

≥98% (HPLC), solid, Ca2+ release blocker, Calbiochem^®

• Synonyma: Ryanodine, High Purity
• Empirický vzorec (Hillův zápis): C₂₅H₃₅NO₉
• Číslo CAS: 15662-33-6
• Molekulová hmotnost: 493.55
• MDL number: MFCD00151119
• UNSPSC Code: 12352200
• NACRES: NA.77

Vlastnosti

• Název produktu: Ryanodine, High Purity, Naturally occurring alkaloid that blocks the release of Ca²⁺ from the sarcoplasmic reticulum.
• description: Merck USA index - 14, 8307
• Quality Level: 100
• assay: ≥98% (HPLC)
• form: solid
• manufacturer/tradename: Calbiochem^®
• storage condition: OK to freeze; protect from light
• color: white
• solubility: water: 1 mg/mL; methanol: 20 mg/mL
• shipped in: ambient
• storage temp.: 10-30°C
• SMILES string: [nH]1c(ccc1)C(=O)O[C@H]2[C@@]3([C@]4([C@]65O[C@]([C@]4([C@@]2(O)C(C)C)C)(C[C@]3([C@]6(CC[C@@H]([C@H]5O)C)O)C)O)O)O
• InChI: 1S/C25H35NO9/c1-12(2)22(31)17(34-16(28)14-7-6-10-26-14)23(32)18(4)11-21(30)19(22,5)25(23,33)24(35-21)15(27)13(3)8-9-20(18,24)29/h6-7,10,12-13,15,17,26-27,29-33H,8-9,11H2,1-5H3/t13-,15+,17+,18-,19-,20-,21-,22+,23+,24+,25+/m0/s1
• InChI key: JJSYXNQGLHBRRK-YSOSZROBSA-N

Popis

General description

Naturally occurring alkaloid that blocks the release of Ca²⁺ from the sarcoplasmic reticulum. Has many complex effects on Ca²⁺ transport and action in muscle. Purified from Ryanodine Mixture.

Biochem/physiol Actions

Cell permeable: no

Primary Target
Ca2+ transport and action in muscle

Product does not compete with ATP.

Reversible: no

Warning

Toxicity: Harmful (C)

Reconstitution

Following reconstitution, refrigerate (4°C). Stock solutions are stable for up to 1 month at 4°C.

Other Notes

Sorrentino, V., and Volpe, P. 1993. Trends Pharmacol. Sci.14, 98.
Sabbadini, R., et al. 1992. J. Biol. Chem.267, 15475.
Feher, J.J., and Lipford, G.B. 1985. Biochim. Biophys. Acta813, 77.
Marban, E., and Wier, W.G. 1985. Circ. Res.56, 133.
Sukto, J.L., et al. 1985. Fed. Proc.44, 2984.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Bezpečnostní informace

• pictograms: GHS07,GHS09
• signalword: Warning
• hcodes: H302 + H312,H410
• pcodes: P264 - P273 - P280 - P301 + P312 - P302 + P352 + P312 - P362 + P364
• Hazard Classifications: Acute Tox. 4 Dermal - Acute Tox. 4 Oral - Aquatic Acute 1 - Aquatic Chronic 1
• Storage Class: 11 - Combustible Solids
• wgk_germany: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable