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N-073

Supelco

Nimetazepam solution

1.0 mg/mL in methanol, ampule of 1 mL, certified reference material, Cerilliant®

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About This Item

Empirický vzorec (Hillův zápis):
C16H13N3O3
Číslo CAS:
2011-67-8
Molekulová hmotnost:
295.29
MDL number:
MFCD00242916
UNSPSC Code:
41116107
PubChem Substance ID:
329818453
NACRES:
NA.24

grade

certified reference material

form

liquid

feature

Snap-N-Spike®/Snap-N-Shoot®

packaging

ampule of 1 mL

manufacturer/tradename

Cerilliant®

drug control

Narcotic Licence Schedule B (Switzerland); psicótropo (Spain); Decreto Lei 15/93: Tabela IV (Portugal)

concentration

1.0 mg/mL in methanol

technique(s)

gas chromatography (GC): suitable
liquid chromatography (LC): suitable

application(s)

clinical testing

format

single component solution

storage temp.

−20°C

SMILES string

CN1C(=O)CN=C(c2ccccc2)c3cc(ccc13)[N+]([O-])=O

InChI

1S/C16H13N3O3/c1-18-14-8-7-12(19(21)22)9-13(14)16(17-10-15(18)20)11-5-3-2-4-6-11/h2-9H,10H2,1H3

InChI key

GWUSZQUVEVMBPI-UHFFFAOYSA-N

Související kategorie

General description

Nimetazepam, marketed as the benzodiazepine drug Erimin, is prescribed for the treatment of stress or short-term severe insomnia in patients who have difficulty falling asleep or maintaining sleep. Cases of abuse have been reported from Southeast Asian countries including Thailand, Malaysia, Singapore, and Hong Kong to states such as Alabama and North Carolina. Although not used therapeutically in the US, the drug is known for its use to soften the comedown after use of methamphetamine or other stimulants.

Application


  • Advanced Analytical Techniques for Benzodiazepines: Nimetazepam has been included in studies using ultra-high performance liquid chromatography coupled with high-resolution time-of-flight mass spectrometry. This methodology is pivotal for the precise analysis of designer benzodiazepines and their pharmacokinetic properties, enhancing research in sedative biochemical studies and psychoactive drug research (Tomková et al., 2017).

  • Forensic and Clinical Toxicology: Development and validation of gas chromatography-mass spectrometry methods for benzodiazepine drugs, including nimetazepam, highlight its application in both clinical and forensic toxicology. This approach facilitates the accurate detection and quantification of benzodiazepines in biological specimens, aiding in the management of conditions such as sleep disorders and anxiety (Papoutsis et al., 2010).

Legal Information

CERILLIANT is a registered trademark of Merck KGaA, Darmstadt, Germany
Snap-N-Shoot is a registered trademark of Cerilliant Corporation
Snap-N-Spike is a registered trademark of Merck KGaA, Darmstadt, Germany

related product

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Popis
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A-098

7-Aminonimetazepam solution, 100 μg/mL in acetonitrile, ampule of 1 mL, certified reference material, Cerilliant®

A-913

7-Aminonitrazepam solution, 1.0 mg/mL in acetonitrile, ampule of 1 mL, certified reference material, Cerilliant®

B-033

Benzodiazepine Multi-component Mixture-8 solution, 250 μg/mL each component in acetonitrile, ampule of 1 mL, certified reference material, Cerilliant®

IMF-020S

iMethod Test Kit for Benzodiazepines with Synthetic Urine, kit of 23 × 1.0 mL ampules, certified reference material, Cerilliant®

F-907

Flunitrazepam solution, 1.0 mg/mL in methanol, ampule of 1 mL, certified reference material, Cerilliant®

F-915

Flunitrazepam-d7, 100 μg/mL in methanol, ampule of 1 mL, certified reference material, Cerilliant®

N-901

Nitrazepam-d5, 100 μg/mL in acetonitrile, ampule of 1 mL, certified reference material, Cerilliant®

N-906

Nitrazepam solution, 1.0 mg/mL in acetonitrile, ampule of 1 mL, certified reference material, Cerilliant®

N-131

Nimetazepam-D3 solution, 100 μg/mL in methanol, certified reference material, ampule of 1 mL, Cerilliant®

signalword

Danger

Hazard Classifications

Acute Tox. 3 Dermal - Acute Tox. 3 Inhalation - Acute Tox. 3 Oral - Flam. Liq. 2 - STOT SE 1

target_organs

Eyes

Storage Class

3 - Flammable liquids

wgk_germany

WGK 1

flash_point_f

49.5 °F - closed cup

flash_point_c

9.7 °C - closed cup

Osvědčení o analýze (COA)

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Navštívit knihovnu dokumentů

H Saito et al.
Research communications in chemical pathology and pharmacology, 46(3), 437-447 (1984-12-01)
This study was undertaken to evaluate fetal toxicity of benzodiazepine derivatives, nitrazepam, oxazepam, nimetazepam, clonazepam, diazepam and chlordiazepoxide. In fetotoxicities induced by the oral administration of these six drugs (100 mg/kg), nitrazepam (NTZ) and nimetazepam caused a great damage to
T Yotsuyanagi et al.
Clinical and experimental dermatology, 23(3), 113-115 (1998-12-23)
The case is presented of a 34-year-old woman with rhabdomyolysis due to massive intake of nimetazepam, a benzodiazepine hypnotic. On admission, the patient had numerous blisters all over the body. One of the blisters in the gluteal region developed into
K Schölermann et al.
Beitrage zur gerichtlichen Medizin, 48, 657-665 (1990-01-01)
The article describes analytical data for the screening and detection of nimetazepam and its major metabolites. The methods comprise thin-layer chromatography, gas chromatography, UV-spectrophotometry, infrared- and mass spectrometry.
L H Peh et al.
Singapore medical journal, 30(1), 72-73 (1989-02-01)
Nimetazepam (Erimin) is a benzodiazepine which has become a new drug of abuse in Singapore. Three cases presenting with psychiatric complications had been treated as inpatients over a period of one and a half years (1986 to 1987) in Woodbridge
Investigations of binding of nimetazepam and some other basic or acid drugs with human and bovine albumin.
J Brandys et al.
Die Pharmazie, 42(5), 350-350 (1987-05-01)
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