930695

4-Aminomethyl-2-(2,6-dioxopiperidin-3-yl)isoindole-1,3-dione hydrochloride

≥95%

• Synonyma: 1H-Isoindole-1,3(2H)-dione, 4-(aminomethyl)-2-(2,6-dioxo-3-piperidinyl) hydrochloride
• Empirický vzorec (Hillův zápis): C₁₄H₁₃N₃O₄ · xHCl
• Číslo CAS: 444287-40-5
• Molekulová hmotnost: 287.27 (free base basis)
• UNSPSC Code: 12352101
• NACRES: NA.26
• MDL number: MFCD30188072

Vlastnosti

• Quality Segment: 100
• assay: ≥95%
• form: powder
• reaction suitability: reagent type: ligand
• functional group: amine
• storage temp.: 2-8°C
• SMILES string: NCC1=C(C(N(C2CCC(NC2=O)=O)C3=O)=O)C3=CC=C1
• InChI: 1S/C14H13N3O4/c15-6-7-2-1-3-8-11(7)14(21)17(13(8)20)9-4-5-10(18)16-12(9)19/h1-3,9H,4-6,15H2,(H,16,18,19)
• InChI key: TUMJPYMYNBEMDD-UHFFFAOYSA-N

Popis

Application

4-Aminomethyl-2-(2,6-dioxopiperidin-3-yl)isoindole-1,3-dione hydrochloride is a functionalized Cereblon ligand used for development of protein degrader building blocks. Contains a terminal amine group, allowing rapid conjugation of carboxyl containing linkers. A basic building block for development of a protein degrader library.

Other Notes

Targeted Protein Degradation by Small Molecules

Destruction of DNA-Binding Proteins by Programmable Oligonucleotide PROTAC (O′PROTAC): Effective Targeting of LEF1 and ERG

Small-Molecule PROTACS: New Approaches to Protein Degradation

Targeted Protein Degradation: from Chemical Biology to Drug Discovery

Impact of linker length on the activity of PROTACs

Technology Spotlight: Degrader Building Blocks for Targeted Protein Degradation
Protein Degrader Building Blocks

Legal Information

PROTAC^® is a registered trademark of Arvinas Operations, Inc., and is used under license.

PROTAC is a registered trademark of Arvinas Operations, Inc., and is used under license

Bezpečnostní informace

• pictograms: GHS08
• signalword: Danger
• hcodes: H360D
• pcodes: P201 - P202 - P280 - P308 + P313 - P405 - P501
• Hazard Classifications: Repr. 1B
• Skladovací třída: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• wgk: WGK 3