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911399

Sigma-Aldrich

Poly(ethylene glycol) methyl ether-block-poly(lactide-co-glycolide)

PEG average Mn 2,000, PLGA average Mn 10,000, lactide:glycolide 80:20

Synonyma:

PEG-PLGA, PEG2K-PLGA10K, mPEG-b-PLGA

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About This Item

Lineární vzorec:
H[(C3H4O2)x(C2H2O2)y]mO[C2H4O]nCH3
UNSPSC Code:
12352112
NACRES:
NA.23

Quality Level

100

form

powder or chunks

feed ratio

lactide:glycolide 80:20

mol wt

PEG average Mn 2,000 (by NMR)
PLGA average Mn 10,000 (by NMR)

color

off-white to faint brown

storage temp.

−20°C

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Související kategorie

Application

This polymer is a amphiphilic diblock copolymer composed of a hydrophilic PEG block and a hydrophobic PLGA block. This biodegradable, biocompatible polymers can self-assemble to form nanoparticles, such as micelles and polymersomes, in both aqueous and non-aqueous media. Due to these properties, these polymers are widely used in polymeric nanoparticle formulation to achieve controlled and targeted delivery of therapeutic agents (e.g. APIs, genetic material, peptides, vaccines, and antibiotics). Additionally, well-defined nanoparticles with tunable size and properties can be prepared by altering the molecular weight ratios between hydrophilic and hydrophobic blocks, as well as by controlling formulation parameters.

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

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Osvědčení o analýze (COA)

Lot/Batch Number
MKCW3552
MKCL4635

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