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909858

Sigma-Aldrich

Carboxylic acid-poly(ethylene glycol)-b-poly(lactide-co-glycolide)

PEG average Mn 5,000, PLGA average Mn 20,000, lactide:glycolide 50:50

Synonyma:

COOH-PEG-PLGA, Carboxylic acid PEG-PLGA

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About This Item

Lineární vzorec:
H[(C3H4O2)x(C2H2O2)y]mO[C2H4O]nC2H3O2
UNSPSC Code:
12352106
NACRES:
NA.23

form

powder or chunks

feed ratio

lactide:glycolide 50:50

mol wt

PEG average Mn 5,000 (by NMR)
PLGA average Mn 20,000 (by NMR)

color

white to tan

storage temp.

−20°C

Application

Carboxylic acid-poly(ethylene glycol)-b-poly(lactide-co-glycolide) is a functionalized, amphiphilic, diblock copolymer composed of a hydrophilic PEG block and a hydrophobic PLGA block. These biodegradable, biocompatible polymers can self-assemble to form nanoparticles, such as micelles and polymersomes, in both aqueous and non-aqueous media. Due to these properties, these polymers are widely used in polymeric nanoparticle formulation to achieve controlled and targeted delivery of therapeutic agents (e.g. APIs, genetic material, peptides, vaccines, and antibiotics). The carboxylic acid functional group on the PEG chain enables rapid and facile surface functionalization, allowing for these materials to be used in applications such as targeted drug delivery.

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

Osvědčení o analýze (COA)

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