764248

Amino-PEG4-alkyne

• Synonyma: 3,6,9,12-Tetraoxapentadec-14-yn-1-amine, Acetylene-PEG4-amine, H₂N-PEG4-propyne, Triethylene glycol 2-aminoethyl propargyl ether
• Empirický vzorec (Hillův zápis): C₁₁H₂₁NO₄
• Číslo CAS: 1013921-36-2
• Molekulová hmotnost: 231.29
• MDL number: MFCD22380736
• UNSPSC Code: 12352106
• PubChem Substance ID: 329767109
• NACRES: NA.22

Vlastnosti

• form: liquid
• reaction suitability: reaction type: click chemistry; reagent type: cross-linking reagent
• functional group: alkyne; amine
• storage temp.: −20°C
• SMILES string: NCCOCCOCCOCCOCC#C
• InChI: 1S/C11H21NO4/c1-2-4-13-6-8-15-10-11-16-9-7-14-5-3-12/h1H,3-12H2
• InChI key: QDLPAHLHHBCWOW-UHFFFAOYSA-N

Popis

Application

Heterobifunctional linker enabling the connection of an azide containing compound or biomolecule to one with a carboxylic acid. The amine group can be linked to a carboxylic acid through standard coupling procedures (EDC, product #39391, etc...) and the terminal alkyne will react with azides via copper-catalyzed 1,3-dipolar cycloaddition click chemistry. The hydrophilic PEG spacer adds to the water solubility of this reagent, allowing for easy modification of carboxylic acid containing biomolecules such as antibodies, proteins and peptides with the terminal alkyne. The PEG spacer also reduces aggregation of modified proteins stored in solution by adding hydrophilic character.

Amino-PEG4-alkyne may be used to synthesize alkynyl-functionalized iron oxide nanoparticles (IONPs) for preparing glycopolymer-based iron oxide nanoparticles (GIONs) for potential bioscience applications.

Bezpečnostní informace

• Storage Class: 10 - Combustible liquids
• wgk_germany: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable