558958

4-Chlorobenzyl bromide

97%

• Synonyma: α-Bromo-p-chlorotoluene, 1-(Bromomethyl)-4-chlorobenzene, 1-Chloro-4-bromomethylbenzene, p-Chlorobenzyl bromide
• Lineární vzorec: ClC₆H₄CH₂Br
• Číslo CAS: 622-95-7
• Molekulová hmotnost: 205.48
• EC Number: 210-760-7
• MDL number: MFCD00040714
• UNSPSC Code: 12352100
• PubChem Substance ID: 24879785
• NACRES: NA.22

Vlastnosti

• assay: 97%
• form: solid
• mp: 48-52 °C (lit.)
• functional group: bromo; chloro
• SMILES string: Clc1ccc(CBr)cc1
• InChI: 1S/C7H6BrCl/c8-5-6-1-3-7(9)4-2-6/h1-4H,5H2
• InChI key: KQNBRMUBPRGXSL-UHFFFAOYSA-N

Popis

General description

4-Chlorobenzyl bromide undergoes carbonylation in the presence of dimer of chloro(1,5-cyclooctadiene)rhodium(I) to yield the corresponding phenylacetic acid. It can be synthesized by reacting 4-chlorobenzyl alcohol with bromodimethylsulfonium bromide (BDMS) It can also be synthesized by refluxing a mixture of 4-chlorobenzaldehyde, chlorotrimethylsilane, 1,1,3,3-tetramethyldisiloxane and lithium bromide.

Application

4-Chlorobenzyl bromide may be used to synthesize 1-(4-chlorobenzyl)-2-(pyrrolidin-1-yl-methyl)-1H-benzimidazole dihydrochloride

Packaging

4-Chlorobenzyl bromide may be used to synthesize:

• 1-[1-[2-[(4-chlorobenzyl)thio]phenyl]vinyl]-1H-imidazole
• 6-[4-(4-chlorobenzyl)piperazinyl]chromane
• N,N′-bis(4-chlorobenzyl)piperazine
• N-(4-chlorobenzyl)piperazine

Bezpečnostní informace

• pictograms: GHS05
• signalword: Danger
• hcodes: H314
• pcodes: P260 - P280 - P303 + P361 + P353 - P304 + P340 + P310 - P305 + P351 + P338 - P363
• Hazard Classifications: Skin Corr. 1B
• Storage Class: 8A - Combustible corrosive hazardous materials
• wgk_germany: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable
• ppe: Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges