530301

2-(Chloromethyl)-3,4-dimethoxypyridine hydrochloride

97%

• Synonyma: 2-(Chloromethyl)-3,4-dimethoxypyridinium hydrochloride
• Empirický vzorec (Hillův zápis): C₈H₁₁Cl₂NO₂
• Číslo CAS: 72830-09-2
• Molekulová hmotnost: 224.08
• Beilstein/REAXYS Number: 5360726
• EC Number: 416-440-5
• MDL number: MFCD02181083
• UNSPSC Code: 12352100
• PubChem Substance ID: 24877740
• NACRES: NA.22

Vlastnosti

• assay: 97%
• mp: 155 °C (dec.) (lit.)
• SMILES string: Cl[H].COc1ccnc(CCl)c1OC
• InChI: 1S/C8H10ClNO2.ClH/c1-11-7-3-4-10-6(5-9)8(7)12-2;/h3-4H,5H2,1-2H3;1H
• InChI key: YYRIKJFWBIEEDH-UHFFFAOYSA-N

Popis

General description

2-(Chloromethyl)-3,4-dimethoxypyridine hydrochloride (CDP) can be synthesized using maltol as a starting material. CDP and DMS (dimethyl sulfate) are used in the preparation of pantoprazole sodium (PPS), an antiulcerative drug. The quantification of CDP and DMS in PPS can be done simultaneously by gas chromatography–mass spectrometry (GC-MS) method.

Application

2-(Chloromethyl)-3,4-dimethoxypyridine hydrochloride may be used as a precursor for the preparation [(2-pyridyl)-2-ethyl]-[3,4-dimethoxy-(2-pyridylmethyl)]-N-methylamine.

Bezpečnostní informace

• pictograms: GHS08,GHS05,GHS07,GHS09
• signalword: Danger
• hcodes: H302 + H312,H315,H317,H318,H373,H411
• pcodes: P273 - P280 - P305 + P351 + P338
• Hazard Classifications: Acute Tox. 4 Dermal - Acute Tox. 4 Oral - Aquatic Chronic 2 - Eye Dam. 1 - Skin Irrit. 2 - Skin Sens. 1 - STOT RE 2
• Storage Class: 11 - Combustible Solids
• wgk_germany: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable
• ppe: dust mask type N95 (US), Eyeshields, Faceshields, Gloves