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142824

Sigma-Aldrich

1-Methyl-1-cyclohexanecarboxylic acid

99%

Přihlásitk zobrazení cen stanovených pro organizaci a smluvních cen


About This Item

Lineární vzorec:
CH3C6H10CO2H
Číslo CAS:
Molekulová hmotnost:
142.20
EC Number:
MDL number:
UNSPSC Code:
12352100
PubChem Substance ID:
NACRES:
NA.22

assay

99%

form

solid

bp

234 °C (lit.)

mp

36-39 °C (lit.)

functional group

carboxylic acid

SMILES string

CC1(CCCCC1)C(O)=O

InChI

1S/C8H14O2/c1-8(7(9)10)5-3-2-4-6-8/h2-6H2,1H3,(H,9,10)

InChI key

REHQLKUNRPCYEW-UHFFFAOYSA-N

General description

1-Methyl-1-cyclohexanecarboxylic acid is the structural analog of valproic acid and its pharmacokinetic action has been studied in female Sprague-Dawley rats.

Application

1-Methyl-1-cyclohexanecarboxylic acid was used as internal standard during the determination of valproic acid metabolites.

Biochem/physiol Actions

1-Methyl-1-cyclohexanecarboxylic acid is an anticonvulsant drug and causes maturation of murine neuroblastoma cells in vitro.

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

213.8 °F - closed cup

flash_point_c

101.00 °C - closed cup

ppe

Eyeshields, Gloves, type N95 (US)


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Effects on the cytoskeleton of a new inducer of the neuroblastoma morphological differentiation.
M M Portier et al.
Biochemical and biophysical research communications, 96(4), 1610-1618 (1980-10-31)
S A Fischkoff et al.
Journal of biological response modifiers, 3(2), 132-137 (1984-01-01)
The anticonvulsant drug 1-methyl-1-cyclohexanecarboxylic acid ( MCCA ) has been shown to cause maturation of murine neuroblastoma cells in vitro at concentrations that are pharmacologically achievable. HL-60 human promyelocytic leukemia cells cultured with this drug underwent a dose-dependent decrease in
J L Vayssière et al.
Biochemical and biophysical research communications, 120(2), 411-419 (1984-04-30)
The evolution of three major mit-proteins was followed in neuroblastoma cells cultured in different conditions of differentiation. 1 methyl cyclohexane carboxylic acid (CCA) was found to stimulate the synthesis of the three mit-protein markers. This result, compared to the effects
A J Sadeque et al.
The Journal of pharmacology and experimental therapeutics, 283(2), 698-703 (1997-11-14)
Cytochrome P450-dependent desaturation of the anticonvulsant drug valproic acid (VPA) results in formation of the hepatotoxin, 4-ene-VPA. Polytherapy with other anticonvulsants which are known P450 inducers increases the flux through this bioactivation pathway. The aim of the present study was
P Benoit et al.
Neuropharmacology, 21(12), 1239-1244 (1982-12-01)
The effect of an anticonvulsant compound (Simiand, Ferrandes, Lacolle and Eymard, 1979), 1-methyl cyclohexane carboxylic acid (CCA), upon the electrical activity of Purkinje cells (PCs) was studied in the cerebellar cortex of the rat in vivo. Cyclohexane carboxylic acid (200-400

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