B5399

(±)-Baclofen

≥98% (HPLC), solid

• Sinónimos: (±)-β-(Aminomethyl)-4-chlorobenzenepropanoic acid, Lioresal
• Fórmula empírica (notación de Hill): C₁₀H₁₂ClNO₂
• Número de CAS: 1134-47-0
• Peso molecular: 213.66
• Número CE: 214-486-9
• Número MDL: MFCD00055143
• Código UNSPSC: 12352200
• ID de la sustancia en PubChem: 24278146
• NACRES: NA.32

Propiedades

• Nivel de calidad: 100
• Ensayo: ≥98% (HPLC)
• Formulario: solid
• color: white to very faintly yellow
• solubilidad: 1 M HCl: 50 mg/mL
• temp. de almacenamiento: 2-8°C
• cadena SMILES: ClC1=CC=C(C(CN)CC(O)=O)C=C1
• InChI: 1S/C10H12ClNO2/c11-9-3-1-7(2-4-9)8(6-12)5-10(13)14/h1-4,8H,5-6,12H2,(H,13,14)
• Clave InChI: KPYSYYIEGFHWSV-UHFFFAOYSA-N
• Información sobre el gen: human ... GABBR1(2550) , GABBR2(9568) ; rat ... Gabbr1(81657) , Gabra2(29706)

Descripción

Aplicación

(±)-Baclofen has been used as γ-aminobutyric acid receptor B GABA_B receptor agonist:

• as well as control GABAergic drug to test its protective effects on 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced dopaminergic toxicity
• to test its effects on in vivo motor function tests and performance of mutant mice
• to test its excitability effect on dopaminergic (DA) neurons of the ventral tegmental area (VTA)
• to test its effect in reducing dendritic excitability in Purkinje neurons

Acciones bioquímicas o fisiológicas

Baclofen, a γ-aminobutyric acid (GABA) analog, possesses myorelaxant properties Being a γ-aminobutyric acid receptor B (GABA_B) agonist, baclofen may be involved in the potentiation of dendritic potassium K⁺ channels. It may be useful in blocking transient lower esophageal sphincter relaxation (TLESR) in gastroesophageal reflux disease (GERD). Baclofen may also have scope for treating addictive especially, in alcohol use disorder (AUD).

GABA_B receptor agonist; skeletal muscle relaxant; antispastic agent.

Información de seguridad

• Pictogramas: GHS06
• Palabra de señalización: Danger
• Frases de peligro: H301
• Consejos de prudencia: P264 - P270 - P301 + P310 - P405 - P501
• Clasificaciones de peligro: Acute Tox. 3 Oral
• Código de clase de almacenamiento: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• Clase de riesgo para el agua (WGK): WGK 3
• Punto de inflamabilidad (°F): Not applicable
• Punto de inflamabilidad (°C): Not applicable
• Equipo de protección personal: Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges