M1523

Muscimol

≥98% (TLC), powder, GABAA receptor agonist.

• Sinónimos: 3-Hydroxy-5-aminomethyl-isoxazole, 5-Aminomethyl-3-hydroxy-isoxazole, 5-Aminomethyl-3-isoxazolol, Agarine, Pantherine
• Fórmula empírica (notación de Hill): C₄H₆N₂O₂
• Número de CAS: 2763-96-4
• Peso molecular: 114.10
• Beilstein: 1618960
• Número CE: 220-430-4
• Número MDL: MFCD00057894
• Código UNSPSC: 12352200
• ID de la sustancia en PubChem: 24896662
• NACRES: NA.77

Propiedades

• Nombre del producto: Muscimol, powder
• Formulario: powder
• Nivel de calidad: 200
• color: white to off-white
• temp. de almacenamiento: 2-8°C
• cadena SMILES: NCC1=CC(=O)NO1
• InChI: 1S/C4H6N2O2/c5-2-3-1-4(7)6-8-3/h1H,2,5H2,(H,6,7)
• Clave InChI: ZJQHPWUVQPJPQT-UHFFFAOYSA-N
• Información sobre el gen: rat ... Gabra2(29706)

Descripción

Descripción general

Muscimol is a psychoactive isoxazole component, which is found in Amanita muscaria and related mushrooms. It lowers cerebral glucose metabolism and increases the level of 5-hydroxytryptamine in brain. Muscimol has hallucinogenic effects. It is associated with distorted perceptions, nausea and vomiting.

Aplicación

Muscimol has been used:

• to reduce conditioned fear-expression in lateral amygdala (LA)
• to eliminate cortical cell response in ferrets
• to inactivate lateral magnocellular nucleus of the nidopallium (LMAN) in zebra finches

Acciones bioquímicas o fisiológicas

GABA_A receptor agonist.

Características y beneficios

This compound is a featured product for Neuroscience research. Click here to discover more featured Neuroscience products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

This compound is featured on the GABAA Receptors and GABAC Receptors pages of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Información de seguridad

• Pictogramas: GHS06
• Palabra de señalización: Danger
• Frases de peligro: H300,H336
• Consejos de prudencia: P261 - P264 - P271 - P301 + P310 - P304 + P340 + P312 - P403 + P233
• Clasificaciones de peligro: Acute Tox. 2 Oral - STOT SE 3
• Órganos de actuación: Central nervous system
• Código de clase de almacenamiento: 6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials
• Clase de riesgo para el agua (WGK): WGK 3
• Punto de inflamabilidad (°F): Not applicable
• Punto de inflamabilidad (°C): Not applicable
• Equipo de protección personal: Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges