276170
N,N-Dimethylbenzamide
99%
Sinónimos:
DMBZ
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About This Item
Fórmula lineal:
C6H5CON(CH3)2
Número de CAS:
Peso molecular:
149.19
EC Number:
MDL number:
UNSPSC Code:
12352100
PubChem Substance ID:
NACRES:
NA.22
Productos recomendados
assay
99%
form
solid
bp
132-133 °C/15 mmHg (lit.)
mp
43-45 °C (lit.)
functional group
amide
SMILES string
CN(C)C(=O)c1ccccc1
InChI
1S/C9H11NO/c1-10(2)9(11)8-6-4-3-5-7-8/h3-7H,1-2H3
InChI key
IMNDHOCGZLYMRO-UHFFFAOYSA-N
General description
N,N-Dimethylbenzamide is a hydrotropic agent and its ability to solubilize drugs with low aqueous solubility has been investigated. It reacts with PhLnI complexes (Ln-Eu, Sm, Yb) to yield benzophenone in good yields. Deuterium exchange labelling experimets on N,N-dimethylbenzamide using [IrH2(Me2CO)2(PPh3)2]BF4 as catalyst and deuterium gas as the source of isotope has been conducted.
Application
Reagent for deoxygenation of secondary alcohols.
signalword
Warning
hcodes
Hazard Classifications
Acute Tox. 4 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
target_organs
Respiratory system
Storage Class
11 - Combustible Solids
wgk_germany
WGK 3
flash_point_f
235.4 °F - closed cup
flash_point_c
113 °C - closed cup
ppe
dust mask type N95 (US), Eyeshields, Gloves
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Deuterium exchange labelling of substituted aromatics using [IrH2 (Me2CO) 2 (PPh3)2] BF4.
Heys JR, et al.
Journal of Labelled Compounds & Radiopharmaceuticals, 33(5), 431-438 (1993)
L R Hall et al.
The Journal of biological chemistry, 265(21), 12349-12355 (1990-07-25)
Liver microsomal cytochrome P-450 readily N-dealkylates N,N-dimethylamides. N-Methyl-N-hydroxymethyl amides were isolated as intermediates and characterized by gas chromatography-mass spectrometry as their trimethylsilyl ethers. Intramolecular kinetic deuterium isotope effects measured for the enzymic N-demethylation of a series of 12 aromatic and
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Polymer micelles have been used widely for delivery of poorly water-soluble drugs. Such drug delivery, however, has been based primarily on hydrophobic interactions. For better drug loading and improved stability, hydrotropic polymer micelles were used. To develop a versatile polymer
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The solubilizing ability of two aromatic hydrotropes, N,N-diethylnicotinamide (DENA) and N,N-dimethylbenzamide (DMBA), was investigated using a set of 13 poorly soluble, structurally diverse drugs. The number of aromatic rings in the solute molecule has a very strong effect on the
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