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36295

Sigma-Aldrich

2,3-Dichloro-1-propanol

≥97.0% (GC)

Sinónimos:

Glycerol-α,β-dichlorohydrin

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About This Item

Fórmula lineal:
ClCH2CHClCH2OH
Número de CAS:
616-23-9
Peso molecular:
128.99
Beilstein/REAXYS Number:
1732060
EC Number:
210-470-0
MDL number:
MFCD00040446
UNSPSC Code:
12352100
PubChem Substance ID:
57649508
NACRES:
NA.22

assay

≥97.0% (GC)

density

1.360 g/mL at 20 °C (lit.)

SMILES string

OCC(Cl)CCl

InChI

1S/C3H6Cl2O/c4-1-3(5)2-6/h3,6H,1-2H2

InChI key

ZXCYIJGIGSDJQQ-UHFFFAOYSA-N

General description

2,3-Dichloro-1-propanol belongs to the group of chloropropanols. Inhibitory effects of 2,3-dichloro-1-propanol on T cell both in vivo and in vitro is reported. Improved enantioselective resolution of (R,S)-2,3-dichloro-1-propanol to (S)-2, 3-dichloro-1-propanol by whole cells of a recombinant Escherichia coli in n-heptane-aqueous biphasic system is reported.

Application

2,3-Dichloro-1-propanol may be employed as carbon and energy supplement for the growth of Pseudomonas putida strain (MC4).

pictograms

Skull and crossbones
GHS06

signalword

Danger

Hazard Classifications

Acute Tox. 2 Dermal - Acute Tox. 3 Oral - Eye Irrit. 2

Storage Class

6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials

wgk_germany

WGK 3

flash_point_f

199.4 °F

flash_point_c

93 °C

ppe

Eyeshields, Faceshields, Gloves, type ABEK (EN14387) respirator filter

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Jing Lu et al.
International immunopharmacology, 17(2), 321-328 (2013-07-16)
2,3-Dichloro-1-propanol (2,3-DCP) is a member of a group of chemicals known as chloropropanols. Currently, immunotoxicity of 2,3-DCP has not been reported. In the present study, we studied its inhibitory effects on T cell both in vivo and in vitro. The
Shu-Ping Zou et al.
Journal of biotechnology, 188, 42-47 (2014-08-26)
The enantioselective resolution of (R,S)-2,3-dichloro-1-propanol ((R,S)-DCP) to (S)-DCP by whole cells of a recombinant Escherichia coli expressing halohydrin dehalogenase (HHDH) activity was limited by product inhibition. To solve this problem to improve the productivity of (S)-DCP, an n-heptane-aqueous biphasic system
K Imazu et al.
Journal of UOEH, 14(1), 73-76 (1992-03-01)
We investigated the toxicity of dichloropropanols (DCPs) in hematological findings and serum chemistry. The solutions of two isomers of DCPs, 1,3-dichloro-2-propanol (DC2P) and 2,3-dichloro-1-propanol (DC1P) were dissolved in saline at the concentration of 100 mg/ml, and 0.1 ml of each
Ijaz Gul et al.
Biotechnology and applied biochemistry, 67(4), 685-692 (2020-02-18)
Epoxides are widely used chemicals, the determination of which is of paramount importance. Herein, we present an enzyme-based approach for noninstrumental detection of epoxides in standard solution and environmental samples. Halohydrin dehalogenase (HheC) as a biological recognition element and epichlorohydrin
Yoshiki Kuroda et al.
Journal of UOEH, 24(3), 271-280 (2002-09-19)
A rare outbreak of acute hepatic damage in workers exposed to dichloropropanols was reported in 1992. As there are no detailed reports of dichloropropanols (DCPs) toxicity and its mechanism, we reviewed the toxicity of dichloropropanols using our results. 1) A
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