X3004

XAV939

≥98% (HPLC), powder, tankyrase inhibitor

• Sinónimos: 3,5,7,8-Tetrahydro-2-[4-(trifluoromethyl)phenyl]-4H-thiopyrano[4,3-d]pyrimidin-4-one
• Fórmula empírica (notación de Hill): C₁₄H₁₁F₃N₂OS
• Número de CAS: 284028-89-3
• Peso molecular: 312.31
• Número MDL: MFCD16879017
• Código UNSPSC: 12352200
• ID de la sustancia en PubChem: 329830802
• NACRES: NA.77

Propiedades

• Nombre del producto: XAV939, ≥98% (HPLC)
• Ensayo: ≥98% (HPLC)
• Formulario: powder
• color: white to beige
• solubilidad: DMSO: 5 mg/mL, clear
• temp. de almacenamiento: room temp
• cadena SMILES: FC(F)(F)c1ccc(cc1)C2=NC3=C(CSCC3)C(=O)N2
• InChI: 1S/C14H11F3N2OS/c15-14(16,17)9-3-1-8(2-4-9)12-18-11-5-6-21-7-10(11)13(20)19-12/h1-4H,5-7H2,(H,18,19,20)
• Clave InChI: KLGQSVMIPOVQAX-UHFFFAOYSA-N

Descripción

Aplicación

XAV939 has been used in the inhibition

• of tankyrase in neuroblastoma cell lines
• of diphtheria toxin-like ADP-ribosyltransferases (ARTD) in medulloblastoma cells
• of wnt signalling in human induced pluripotent stem cells (hiPSCs)

Acciones bioquímicas o fisiológicas

XAV939 is a Tankyrase inhibitor (thereby inhibiting Wnt / β-catenin signaling)

XAV939 is a cell-permeable dihydrothiopyranopyrimidinol, which elicits anti-tumor functionality against colon, lung, breast and liver cancer. It binds to catalytic poly-ADP-ribose polymerase (PARP) domain of the tankyrase enzyme resulting in β-catenin destruction. It also inhibits tankyrase in neuroblastoma promoting apoptosis in tumor cells.

Características y beneficios

This compound is a featured product for Gene Regulation research. Click here to discover more featured Gene Regulation products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

Otras notas

XAV939 has been expertly reviewed and recommended by the Chemical Probes Portal. For more information, please visit the XAV939 probe summary on the Chemical Probes Portal website.

Información de seguridad

• Pictogramas: GHS07
• Palabra de señalización: Warning
• Frases de peligro: H302
• Consejos de prudencia: P264 - P270 - P301 + P312 - P501
• Clasificaciones de peligro: Acute Tox. 4 Oral
• Código de clase de almacenamiento: 11 - Combustible Solids
• Clase de riesgo para el agua (WGK): WGK 3
• Punto de inflamabilidad (°F): Not applicable
• Punto de inflamabilidad (°C): Not applicable