SML0314

CGP77675

≥98% (HPLC), Src kinase inhibitor, powder

• Sinónimos: 1-(2-{4-[4-Amino-5-(3-methoxyphenyl)-7H-pyrrolo[2,3-d]pyrimidin-7-yl]phenyl}ethyl)piperidin-4-ol, 1-(4-(4-Amino-5-(3-methoxyphenyl)-7H-pyrrolo[2,3-d]pyrimidin-7-yl)phenethyl)piperidin-4-ol, CGP 77675, CGP-77675
• Fórmula empírica (notación de Hill): C₂₆H₂₉N₅O₂
• Número CAS: 234772-64-6
• Peso molecular: 443.54
• UNSPSC Code: 12352200
• PubChem Substance ID: 329825319
• NACRES: NA.77
• MDL number: MFCD20039929
• Assay: ≥98% (HPLC)
• Form: powder

Propiedades

• Nombre del producto: CGP77675, ≥98% (HPLC)
• Quality Segment: 100
• assay: ≥98% (HPLC)
• form: powder
• color: white to beige
• solubility: DMSO: >10 mg/mL
• storage temp.: 2-8°C
• SMILES string: COc1cccc(c1)-c2cn(-c3ccc(CCN4CCC(O)CC4)cc3)c5ncnc(N)c25
• InChI: 1S/C26H29N5O2/c1-33-22-4-2-3-19(15-22)23-16-31(26-24(23)25(27)28-17-29-26)20-7-5-18(6-8-20)9-12-30-13-10-21(32)11-14-30/h2-8,15-17,21,32H,9-14H2,1H3,(H2,27,28,29)
• InChI key: WUPXZZWTHIZICK-UHFFFAOYSA-N

Descripción

General description

CGP77675 belongs to the pyrrolopyrimidine class of inhibitors.

Application

CGP77675 has been used in the generation of mouse expanded potential stem cells.

Biochem/physiol Actions

CGP77675 is a potent Src kinase inhibitor.

CGP77675 is a potent Src kinase inhibitor. CGP77675 is selective toward other protein kinases including Cdc2 (>500-fold), epidermal growth factor (EGF) receptor (7.5-fold), vascular endothelial growth factor receptor (>50-fold), and for v-Abl (15-fold) and focal adhesion kinase (Fak) (>25-fold).

CGP77675 prevents hypercalcemia stimulated by interleukin 1β. It is known to offer protection against bone loss in ovariectomized mice. CGP77675 is known for its use in cancer treatment.

Features and Benefits

This compound is a featured product for Kinase Phosphatase Biology research. Click here to discover more featured Kinase Phosphatase Biology products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

Información de seguridad

• Clase de almacenamiento: 11 - Combustible Solids
• ¿Qué está pasando?: WGK 3
• Punto de inflamación (°F): Not applicable
• Punto de inflamación (°C): Not applicable