SRP4915

Vaspin human

recombinant, expressed in E. coli, ≥90% (SDS-PAGE), ≥90% (HPLC)

• Sinónimos: OL-64, SERPINA12, Serpin A12 precursor, Vaspin, Visceral adipose tissue- derived serine protease inhibitor, Visceral adipose-specific serpin
• UNSPSC Code: 12352200
• NACRES: NA.32

Propiedades

• biological source: human
• recombinant: expressed in E. coli
• assay: ≥90% (HPLC); ≥90% (SDS-PAGE)
• form: lyophilized powder
• mol wt: ~47.0 kDa
• packaging: pkg of 25 μg
• storage condition: avoid repeated freeze/thaw cycles
• impurities: endotoxin, tested
• NCBI accession no.: Q8IW75
• shipped in: dry ice
• storage temp.: −70°C
• Gene Information: human ... SPA12(145264)

Descripción

General description

Vaspin (visceral adipose-specific SERPIN), a newly identified adipokine, is a member of serine protease inhibitor family. It is also known as serpin family A member 12 (SERPINA12). The gene encoding this protein is localized on human chromosome 14q32.13. Recombinant human Vaspin produced in E. coli is a single, non-glycosylated polypeptide chain containing 415 amino acids and having a molecular mass of 47kDa.

Biochem/physiol Actions

Vaspin (visceral adipose-specific SERPIN) is also a unique insulin sensitizing adipocytokine in obesity. A recent publication indicates that induction of human vaspin mRNA expression in adipose tissue is regulated in a fat depot-specific manner and could be associated with parameters of obesity, insulin resistance, and glucose metabolism. This protein may be useful as a biomarker with patients with acute myocardial infarction. It is a ligand of the 78kDa glucose-regulated protein/murine transmembrane protein (GRP78/MTJ-1) complex and has indirect effects on endoplasmic reticulum stress-induced metabolic disorders.

Physical form

1 mg/ml in 20 mM Tris pH-8, 0.2 mM PMSF and 10% glycerol.

Reconstitution

Centrifuge the vial prior to opening. Avoid freeze-thaw cycles.

Información de seguridad

• Storage Class: 13 - Non Combustible Solids
• wgk_germany: nwg