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Merck
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Key Documents

P9389

Sigma-Aldrich

Poly(deoxyguanylic-deoxycytidylic) acid sodium salt

double stranded, alternating copolymer

Sinónimos:

Poly(dG-dC) • Poly(dG-dC)

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About This Item

Número de CAS:
90385-88-9
MDL number:
MFCD00131968
UNSPSC Code:
41106305
NACRES:
NA.51

biological source

synthetic (organic)

Quality Level

200

form

powder or solid

storage temp.

−20°C

General description

Poly(deoxyguanylic-deoxycytidylic) acid (poly(dG-dC)) undergoes salt dependent conformational transition. Under high-salt, it exists as a left-handed double helix and at low-salt it displays B-DNA conformation. However on immobilization, poly(dG-dC) takes up A DNA form.

Application

Poly(deoxyguanylic-deoxycytidylic) acid (Poly(dG-dC) • Poly(dG-dC)) is an alternating copolymer, self-complementary, double-stranded DNA model for conformational studies of DNA structure dynamics and drug interaction.
Poly(deoxyguanylic-deoxycytidylic) acid sodium salt has been used:
  • in electrophoretic mobility shift assay of transcription factor IIIB complex
  • as synthetic copolymers for circular dichroism (CD) spectroscopy studies
  • as a positive control in liquid scintillation counting

Other Notes

Alternating copolymer; self-complementary, form double-stranded complex

Unit Definition

One unit will yield an A260 of 1.0 in 1.0 ml 20 mM sodium phosphate/100 mM NaCl, pH 7.0 (1cm light path).

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

Certificados de análisis (COA)

Busque Certificados de análisis (COA) introduciendo el número de lote del producto. Los números de lote se encuentran en la etiqueta del producto después de las palabras «Lot» o «Batch»

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TFIIIB subunit locations on U6 gene promoter DNA mapped by site-specific protein-DNA photo-cross-linking
Kang JJ, et al.
Febs Letters, 590(10), 1488-1497 (2016)
Salt-dependent dynamic structure of poly (dG-dC) textperiodcentered poly (dG-dC)
Ramstein J and Leng M
Nature, 288(5789), 413-413 (1980)
Poly (dG)-poly (dC) DNA appears shorter than poly (dA)-poly (dT) and possibly adopts an A-related conformation on a mica surface under ambient conditions
Borovok N, et al.
Febs Letters, 581(30), 5843-5846 (2007)
Genomic DNA methylation decreases in response to moderate folate depletion in elderly women-
Rampersaud GC, et al.
American Journal of Clinical Nutrition, 72(4), 998-1003 (2000)
Creina Slator et al.
ACS chemical biology, 11(1), 159-171 (2015-10-22)
The in cellulo catalytic production of reactive oxygen species (ROS) by copper(II) and iron(II) complexes is now recognized as a major mechanistic model in the design of effective cytotoxins of human cancer. The developmental complex, [Cu(o-phthalate)(1,10-phenanthroline)] (Cu-Ph), was recently reported
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