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Documentos

P9764

Sigma-Aldrich

Polydeoxyadenylic acid • Polythymidylic acid sodium salt

double-stranded homopolymer

Sinónimos:

Poly(dA) • Poly(dT)

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About This Item

Número de CAS:
86834-22-2
MDL number:
MFCD00131963
UNSPSC Code:
41106305
NACRES:
NA.51

biological source

synthetic (organic)

Quality Level

200

form

powder

storage temp.

−20°C

InChI

1S/C10H14N5O6P.C10H15N2O8P/c11-9-8-10(13-3-12-9)15(4-14-8)7-1-5(16)6(21-7)2-20-22(17,18)19;1-5-3-12(10(15)11-9(5)14)8-2-6(13)7(20-8)4-19-21(16,17)18/h3-7,16H,1-2H2,(H2,11,12,13)(H2,17,18,19);3,6-8,13H,2,4H2,1H3,(H,11,14,15)(H2,16,17,18)

InChI key

KKVQVIFXABFJCS-UHFFFAOYSA-N

Application

Polydeoxyadenylic acid • Polythymidylic acid (Poly(dA) • Poly(dT)) is a double-stranded homopolymer use as a DNA model for conformational studies of DNA structure dynamics and drug interaction.

Other Notes

Double-stranded homopolymer

Unit Definition

One unit will yield an A260 of 1.0 in 1.0 ml 20 mM sodium phosphate/100 mM NaCl, pH 7.0

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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J Tanha et al.
Molecular immunology, 34(2), 109-113 (1997-02-01)
A large combinatorial phage display library was panned against five nucleic acid antigens, calf thymus DNA, poly[d(GC)], poly[d(AT)], poly(dA) x poly(dT) and poly(rA) x poly(dT). After the third and fourth rounds of panning, many positive clones were selected against poly[d(GC)]
M Thomas et al.
Journal of biomolecular structure & dynamics, 18(6), 858-871 (2001-07-11)
The binding of three analogues of the minor-groove binding antiviral antibiotic distamycin (Dst) with double-stranded (ds)-DNA were monitored using ds-DNA melting temperature (Tm) measurements, ethidium bromide (EtBr) displacement assay, footprinting analysis and induced circular dichroism (ICD). These compounds contained 3-5
Hongjuan Xi et al.
Biochemistry, 50(42), 9088-9113 (2011-08-26)
Recognition of nucleic acids is important for our understanding of nucleic acid structure as well as for our understanding of nucleic acid-protein interactions. In addition to the direct readout mechanisms of nucleic acids such as H-bonding, shape recognition of nucleic
M A Semenov et al.
Biofizika, 39(4), 628-636 (1994-07-01)
IR-spectrometry and thermopiezogravimetry are used to study the structure formation and the water environment of the double-helix Na-poly(dA)-poly(dT) complex in films in the 0-100% interval of the relative humidity (RH). It has been found that three different structures of the
Marta Airoldi et al.
Biopolymers, 75(2), 118-127 (2004-09-10)
CD and uv absorption data showed that high molecular weight poly(dA-dT) . poly(dA-dT), at 298 K, undergoes an acid-induced transition from B-double helix to random coil in NaCl solutions of different concentrations, ranging from 0.005 to 0.600M. Similarly, titration of
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