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Documentos

M6524

Sigma-Aldrich

Methoxamine hydrochloride

Sinónimos:

α-(1-Aminoethyl)-2,5-dimethoxybenzyl alcohol hydrochloride

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About This Item

Fórmula empírica (notación de Hill):
C11H17NO3 · HCl
Número de CAS:
61-16-5
Peso molecular:
247.72
EC Number:
200-499-7
MDL number:
MFCD00058607
UNSPSC Code:
12352116
PubChem Substance ID:
24277785
NACRES:
NA.77

Quality Level

200

storage temp.

2-8°C

SMILES string

Cl[H].COc1ccc(OC)c(c1)C(O)C(C)N

InChI

1S/C11H17NO3.ClH/c1-7(12)11(13)9-6-8(14-2)4-5-10(9)15-3;/h4-7,11,13H,12H2,1-3H3;1H

InChI key

YGRFXPCHZBRUKP-UHFFFAOYSA-N

Gene Information

human ... ADRA1A(148) , ADRA1B(147) , ADRA1D(146)

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Biochem/physiol Actions

α1-adrenoceptor agonist.

Features and Benefits

This compound is featured on the α1-Adrenoceptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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Chandana B Herath et al.
American journal of physiology. Gastrointestinal and liver physiology, 304(1), G99-108 (2012-10-23)
Recent studies have shown that, in cirrhosis, portal angiotensin-(1-7) [Ang-(1-7)] levels are increased and hepatic expression of angiotensin converting enzyme 2 (ACE2) and the Mas receptor are upregulated, but the effects of Ang-(1-7) on hepatic hemodynamics in cirrhosis have not
Sven Francque et al.
Laboratory investigation; a journal of technical methods and pathology, 92(10), 1428-1439 (2012-08-15)
Non-alcoholic fatty liver disease can progress to steatohepatitis and fibrosis, and is also associated with impaired liver regeneration. The pathophysiology remains elusive. We recently showed that severe steatosis is associated with an increase in portal pressure, suggesting liver flow impairment.
Robert H Thiele et al.
Anesthesia and analgesia, 113(2), 284-296 (2011-04-27)
Phenylephrine and methoxamine are direct-acting, predominantly α(1) adrenergic receptor (AR) agonists. To better understand their physiologic effects, we screened 463 articles on the basis of PubMed searches of "methoxamine" and "phenylephrine" (limited to human, randomized studies published in English), as
R H Lee et al.
Journal of neurophysiology, 81(5), 2164-2174 (1999-05-13)
Enhancement of bistability in spinal motoneurons in vivo by the noradrenergic alpha1 agonist methoxamine. Like many types of motoneurons, spinal motoneurons in the adult mammal can exhibit bistable behavior. This means that short periods of excitatory input can initiate long
Alain Frigon et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 31(15), 5579-5588 (2011-04-15)
Extra forces or torques are defined as forces or torques that are larger than would be expected from the input or stimuli, which can be mediated by properties intrinsic to motoneurons and/or to the muscle. The purpose of this study
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Artículos

α1-Adrenoceptor Characteristics and Modulators

Review alpha 1 adrenoceptors as well as their agonists, antagonists, and tissue expression patterns. We suggest several modulators and alternatives for working with a-1 adrenoreceptors.

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