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Documentos

I2753

Sigma-Aldrich

Inosine 3′:5′-cyclic monophosphate sodium salt

≥98%

Sinónimos:

cIMP

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About This Item

Fórmula lineal:
C10H10N4O7PNa
Número de CAS:
41092-64-2
Peso molecular:
352.17
MDL number:
MFCD00057137
UNSPSC Code:
41106305
PubChem Substance ID:
24896007
NACRES:
NA.51

Quality Level

200

assay

≥98%

form

powder

storage temp.

−20°C

SMILES string

[Na].OC1C2OP(O)(=O)OCC2OC1n3cnc4C(=O)N=CNc34

InChI

1S/C10H11N4O7P.Na.H/c15-6-7-4(1-19-22(17,18)21-7)20-10(6)14-3-13-5-8(14)11-2-12-9(5)16;;/h2-4,6-7,10,15H,1H2,(H,17,18)(H,11,12,16);;

InChI key

XIUBZBACWHALEW-UHFFFAOYSA-N

Application

Inosine 3′:5′-cyclic monophosphate (cIMP) is used in studies that compare the substrate specificity and activity of cyclic purines, including the 3′,5′-cyclic monophosphates cAMP and cGMP.

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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Galen E Flynn et al.
The Journal of general physiology, 121(6), 563-582 (2003-05-29)
Cyclic nucleotide-gated (CNG) channels belong to the P-loop-containing family of ion channels that also includes KcsA, MthK, and Shaker channels. In this study, we investigated the structure and rearrangement of the CNGA1 channel pore using cysteine mutations and cysteine-specific modification.
R C Ganassin et al.
Journal of cellular physiology, 160(3), 409-416 (1994-09-01)
The influence of inosine on DNA synthesis by Chinook salmon embryo cells (CHSE-214) was investigated because previously cell number was shown to increase from six- to thirtyfold if inosine was added to the basal medium (L-15) supplemented with either dialyzed
Daisuke Okada et al.
Biochemistry, 41(30), 9672-9679 (2002-07-24)
The effects of cGMP binding on the catalytic activity of cGMP-specific, cGMP-binding phosphodiesterase (PDE5) are unclear because cGMP interacts with both allosteric and catalytic sites specifically. We studied the effects of cGMP on the hydrolysis of a fluorescent substrate analogue
S Wang et al.
The Journal of biological chemistry, 275(43), 33457-33463 (2000-08-10)
The enhancement of the transcription of three synthetic promoters by cNMP-ligated cAMP receptor protein (CRP)/mutant complexes was determined from the transcription yields of a short AAUU transcript in an abortive initiation in vitro transcription assay. The cNMP-ligated CRP and mutants
M S Shapiro et al.
Biophysical journal, 78(5), 2307-2320 (2000-04-25)
In vertebrate olfactory receptors, cAMP produced by odorants opens cyclic nucleotide-gated (CNG) channels, which allow Ca(2+) entry and depolarization of the cell. These CNG channels are composed of alpha subunits and at least two types of beta subunits that are
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